The Innate Immunity Adaptor SARM Translocates to the Nucleus to Stabilize Lamins and Prevent DNA Fragmentation in Response to Pro-Apoptotic Signaling

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Sethman, Chad R. ; Hawiger, Jacek (2013)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 8, issue 7 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3726548, doi: 10.1371/journal.pone.0070994
  • Subject: Signaling in Cellular Processes | Cellular Stress Responses | Research Article | Biology | Molecular Cell Biology | Cell Death | Signal Transduction | Aging and Immunity | Medicine | Immunity | Cellular Structures | Antiapoptotic Signaling | Q | R | Cell Nucleus | Innate Immunity | Inflammation | Science | Apoptotic Signaling | Immunology

Sterile alpha and armadillo-motif containing protein (SARM), a highly conserved and structurally unique member of the MyD88 family of Toll-like receptor adaptors, plays an important role in innate immunity signaling and apoptosis. Its exact mechanism of intracellular ac... View more