The Innate Immunity Adaptor SARM Translocates to the Nucleus to Stabilize Lamins and Prevent DNA Fragmentation in Response to Pro-Apoptotic Signaling
Sethman, Chad R.
- Publisher: Public Library of Science
(issn: 1932-6203, eissn: 1932-6203)
Signaling in Cellular Processes | Cellular Stress Responses | Research Article | Biology | Molecular Cell Biology | Cell Death | Signal Transduction | Aging and Immunity | Medicine | Immunity | Cellular Structures | Antiapoptotic Signaling | Q | R | Cell Nucleus | Innate Immunity | Inflammation | Science | Apoptotic Signaling | Immunology
Sterile alpha and armadillo-motif containing protein (SARM), a highly conserved and structurally unique member of the MyD88 family of Toll-like receptor adaptors, plays an important role in innate immunity signaling and apoptosis. Its exact mechanism of intracellular ac...