Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice

Other literature type, Article English OPEN
Waisberg, Michael; Tarasenko, Tatyana; Vickers, Brandi K; Scott, Bethany L; Willcocks, Lisa C; Molina-Cruz, Alvaro; Pierce, Matthew A; Huang, Chiung-yu; Torres-Velez, Fernando J; Smith, Kenneth; Barillas-Mury, Carolina; Miller, Louis H; Pierce, Susan K; Bolland, Silvia;
  • Publisher: National Academy of Sciences
  • Related identifiers: pmc: PMC3024697, doi: 10.1073/pnas.1017996108, doi: 10.17863/CAM.42437
  • Subject: DNA Primers | Malaria, Cerebral | Mice, Knockout | Mice | Mice, Inbred C57BL | Erythrocytes | Survival Analysis | Receptors, IgG | Reverse Transcriptase Polymerase Chain Reaction | Cytokines | Flow Cytometry | Animals | Female | African Continental Ancestry Group | Lupus Erythematosus, Systemic | Organ Size | Spleen | Brain | Plasmodium berghei | Biological Sciences | Toll-Like Receptor 7 | Enzyme-Linked Immunosorbent Assay | Genetic Predisposition to Disease | Humans | Male
    mesheuropmc: skin and connective tissue diseases | immune system diseases | parasitic diseases

Plasmodium falciparum has exerted tremendous selective pressure on genes that improve survival in severe malarial infections. Systemic lupus erythematosus (SLE) is an autoimmune disease that is six to eight times more prevalent in women of African descent than in women ... View more
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