publication . Article . 2016

Effect of Exercise and Calorie Restriction on Tissue Acylcarnitines, Tissue Desaturase Indices, and Fat Accumulation in Diet-Induced Obese Rats

Adonsia Yating Yang; Manami Kaneko; K. N. Bhanu Prakash; Suresh Anand Sadananthan; Bin Zhu; Megumi Hirayama; Venkatesh Gopalan; Yoshinori Satomi; Takashi Horiguchi; Seigo Ishino; ...
Open Access English
  • Published: 01 May 2016
Abstract
Both exercise and calorie restriction interventions have been recommended for inducing weight-loss in obese states. However, there is conflicting evidence on their relative benefits for metabolic health and insulin sensitivity. This study seeks to evaluate the differential effects of the two interventions on fat mobilization, fat metabolism, and insulin sensitivity in diet-induced obese animal models. After 4 months of ad libitum high fat diet feeding, 35 male Fischer F344 rats were grouped (n = 7 per cohort) into sedentary control (CON), exercise once a day (EX1), exercise twice a day (EX2), 15% calorie restriction (CR1) and 30% calorie restriction (CR2) cohort...
Subjects
free text keywords: Article, Multidisciplinary, Biology, Cohort, Adipose tissue, Endocrinology, medicine.medical_specialty, medicine, Calorie restriction, Carnitine, medicine.drug, Obesity, medicine.disease, Insulin resistance, Lipid metabolism, Diet-induced obese, Internal medicine
58 references, page 1 of 4

Gregg E. W., Cheng Y. J., Narayan K. V., Thompson T. J. & Williamson D. F. The relative contributions of different levels of overweight and obesity to the increased prevalence of diabetes in the United States: 1976–2004. Prev. Med. 45, 348–352 (2007).17889292 [PubMed]

Sullivan P. W., Morrato E. H., Ghushchyan V., Wyatt H. R. & Hill J. O. Obesity, inactivity, and the prevalence of diabetes and diabetes-related cardiovascular comorbidities in the US, 2000–2002. Diabetes Care 28, 1599–1603 (2005).15983307 [OpenAIRE] [PubMed]

Cordain L.et al.Origins and evolution of the Western diet: health implications for the 21st century. Am. J. Clin. Nutr.81, 341–354 (2005).15699220 [OpenAIRE] [PubMed]

Fogelholm M.& Kukkonen‐Harjula, K. Does physical activity prevent weight gain–a systematic review. Obes. Rev.1, 95–111 (2000).12119991 [OpenAIRE] [PubMed]

Fung T. T.et al.Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. Am. J.Clin. Nutr.73, 61–67 (2001).11124751 [OpenAIRE] [PubMed]

Hulver M. W. & Lynis Dohm G. The molecular mechanism linking muscle fat accumulation to insulin resistance. Pro. Nutr. Soc. 63, 375–380 (2004). [OpenAIRE]

Choi Y. S.et al.Associations Between Estimated Desaturase Activity and Insulin Resistance in Korean Boys. Osong. Public. Health Res. Perspect.5, 251–257 (2014).25389510 [OpenAIRE] [PubMed]

Das U. N.A defect in the activity of Δ 6 and Δ 5 desaturases may be a factor predisposing to the development of insulin resistance syndrome. Prostaglandins. Leukot. Essent. Fatty Acids.72, 343–350 (2005).15850715 [PubMed]

Kröger J. & Schulze M. B. Recent insights into the relation of Δ5 desaturase and Δ6 desaturase activity to the development of type 2 diabetes. Curr. Opin. Lipidol. 23, 4–10 (2012).22123669 [PubMed]

Miyazaki M. & Ntambi J. M. Role of stearoyl-coenzyme A desaturase in lipid metabolism. Prostaglandins. Leukot. Essent. Fatty Acids. 68, 113–121 (2003).12538075 [OpenAIRE] [PubMed]

Pan D. A.et al.Skeletal muscle membrane lipid composition is related to adiposity and insulin action. J. Clin. Invest.96, 2802 (1995).8675650 [OpenAIRE] [PubMed]

Vessby B., GUSTAFSSON I. B., Tengblad S., Boberg M. & Andersson A. Desaturation and elongation of fatty acids and insulin action. Ann. N. Y. Acad. Sci. 967, 183–195 (2002).12079847 [PubMed]

Mihalik S. J.et al.Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity(Silver Spring)18, 1695–1700 (2010).20111019 [OpenAIRE] [PubMed]

Koves T. R.et al.Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell. Metab.7, 45–56 (2008).18177724 [OpenAIRE] [PubMed]

Sparks L. M.et al.A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54, 1926–1933 (2005).15983191 [PubMed]

58 references, page 1 of 4
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