Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages.

Article English OPEN
Maggie L Chow; Tiziano Pramparo; Mary E Winn; Cynthia Carter Barnes; Hai-Ri Li; Lauren Weiss; Jian-Bing Fan; Sarah Murray; Craig April; Haim Belinson; Xiang-Dong Fu; Anthony Wynshaw-Boris; Nicholas J Schork; Eric Courchesne;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Genetics,volume 8,issue 3 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: doi: 10.1371/journal.pgen.1002592, pmc: PMC3310790
  • Subject: QH426-470 | Research Article | Biology | Genetics | Neuroscience | Genomics | Medicine
    mesheuropmc: mental disorders

Autism is a highly heritable neurodevelopmental disorder, yet the genetic underpinnings of the disorder are largely unknown. Aberrant brain overgrowth is a well-replicated observation in the autism literature; but association, linkage, and expression studies have not id... View more