Vaginal Lactobacillus isolates inhibit uropathogenic Escherichia coli.

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Atassi, Fabrice ; Brassart, Dominique ; Grob, Philipp ; Graf, Federico ; Servin, Alain, (2006)
  • Publisher: HAL CCSD
  • Related identifiers: doi: 10.1111/j.1574-6968.2006.00163.x
  • Subject: MESH : Hela Cells | MESH : Escherichia coli Infections | MESH : Escherichia coli | [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases | MESH : Cystitis | MESH : Vagina | MESH : Adhesins, Escherichia coli | MESH : Bacterial Adhesion | MESH : Humans | MESH : Lactobacillus | [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology | MESH : Female | MESH : Antibiosis | MESH : Urinary Tract Infections | [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases | [ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology

The purpose of this study was to investigate the antibacterial activities of Lactobacillus jensenii KS119.1 and KS121.1, and Lactobacillus gasserii KS120.1 and KS124.3 strains isolated from the vaginal microflora of healthy women, against uropathogenic, diffusely adhering Afa/Dr Escherichia coli (Afa/Dr DAEC) strains IH11128 and 7372 involved in recurrent cystitis. We observed that some of the Lactobacillus isolates inhibited the growth and decreased the viability of E. coli IH11128 and 7372. In addition, we observed that adhering Lactobacillus strains inhibited adhesion of E. coli IH11128 onto HeLa cells, and inhibited internalization of E. coli IH11128 within HeLa cells.
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