Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes

Article, Other literature type English OPEN
Chaudhary, Natasha ; Gonzalez, Eva ; Chang, Sung-Hee ; Geng, Fuqiang ; Rafii, Shahin ; Altorki, Nasser K. ; McGraw, Timothy E. (2016)
  • Publisher: Elsevier BV
  • Journal: Cell Reports, volume 17, issue 12, pages 3,305-3,318 (issn: 2211-1247)
  • Related identifiers: doi: 10.1016/j.celrep.2016.11.082, pmc: PMC5193245
  • Subject: PI3K-AKT signaling | RAB10 | Article | GLUT4 | PI3-kinase | QH301-705.5 | GLUT1 | E4ORF1 | Biology (General)
    mesheuropmc: viruses | bacteria | nutritional and metabolic diseases | hormones, hormone substitutes, and hormone antagonists | biochemical phenomena, metabolism, and nutrition

Insulin activation of phosphatidylinositol 3-kinase (PI3K) regulates metabolism, including the translocation of the Glut4 glucose transporter to the plasma membrane and inactivation of the FoxO1 transcription factor. Adenoviral protein E4-ORF1 stimulates cellular glucos... View more
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