Adenovirus Protein E4-ORF1 activation of PI3 kinase reveals differential regulation of downstream effector pathways in adipocytes

Article, Other literature type English OPEN
Chaudhary, Natasha; Gonzalez, Eva; Chang, Sung-Hee; Geng, Fuqiang; Rafii, Shahin; Altorki, Nasser K.; McGraw, Timothy E.;
  • Publisher: Elsevier
  • Journal: Cell Reports,volume 17,issue 12,pages3,305-3,318 (issn: 2211-1247)
  • Related identifiers: doi: 10.1016/j.celrep.2016.11.082, pmc: PMC5193245
  • Subject: PI3K-AKT signaling | RAB10 | GLUT4 | Article | PI3-kinase | QH301-705.5 | GLUT1 | E4ORF1 | Biology (General)
    mesheuropmc: viruses | bacteria | nutritional and metabolic diseases | hormones, hormone substitutes, and hormone antagonists | biochemical phenomena, metabolism, and nutrition

Insulin activation of phosphatidylinositol 3-kinase (PI3K) regulates metabolism, including the translocation of the Glut4 glucose transporter to the plasma membrane and inactivation of the FoxO1 transcription factor. Adenoviral protein E4-ORF1 stimulates cellular glucos... View more
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