publication . Article . 2016

Relationship between vacA Types and Development of Gastroduodenal Diseases

Tran Thi Huyen Trang; Tran Thanh Binh; Yoshio Yamaoka;
Open Access English
  • Published: 01 Jun 2016 Journal: Toxins, volume 8, issue 6 (issn: 2072-6651, eissn: 2072-6651, Copyright policy)
  • Publisher: MDPI
Abstract
The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease.
Subjects
mesheuropmc: bacteriabacterial infections and mycosesdigestive system diseases
free text keywords: vacuolation, R, prolonged Helicobacter pylori infection, Review, VacA genotypes, Medicine, H. pylori-mediated diseases
Funded by
NIH| Regulation of CXC chemokine expression by H. pylori.
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK062813-05
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
69 references, page 1 of 5

Ferreira, R.M., Machado, J.C., Letley, D., Atherton, J.C., Pardo, M.L., Gonzalez, C.A., Carneiro, F., Figueiredo, C.. A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens. J. Clin. Microbiol.. 2012; 50: 3983-3989 [OpenAIRE] [PubMed] [DOI]

Memon, A.A., Hussein, N.R., Miendje Deyi, V.Y., Burette, A., Atherton, J.C.. Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: A matched case-control study. J. Clin. Microbiol.. 2014; 52: 2984-2989 [OpenAIRE] [PubMed] [DOI]

Shimoyama, T., Yoshimura, T., Mikami, T., Fukuda, S., Crabtree, J.E., Munakata, A.. Evaluation of Helicobacter pylori vacA genotype in Japanese patients with gastric cancer. J. Clin. Pathol.. 1998; 51: 299-301 [OpenAIRE] [PubMed] [DOI]

Cover, T.L., Tummuru, M.K., Cao, P., Thompson, S.A., Blaser, M.J.. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J. Biol. Chem.. 1994; 269: 10566-10573 [PubMed]

Atherton, J.C., Cao, P., Peek, R.M., Tummuru, M.K., Blaser, M.J., Cover, T.L.. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem.. 1995; 270: 17771-17777 [PubMed]

Forsyth, M.H., Atherton, J.C., Blaser, M.J., Cover, T.L.. Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains. Infect. Immun.. 1998; 66: 3088-3094 [OpenAIRE] [PubMed]

Letley, D.P., Atherton, J.C.. Natural diversity in the n terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity. J. Bacteriol.. 2000; 182: 3278-3280 [OpenAIRE] [PubMed] [DOI]

Strobel, S., Bereswill, S., Balig, P., Allgaier, P., Sonntag, H.G., Kist, M.. Identification and analysis of a new vacA genotype variant of Helicobacter pylori in different patient groups in germany. J. Clin. Microbiol.. 1998; 36: 1285-1289 [OpenAIRE] [PubMed]

Van Doorn, L.J., Figueiredo, C., Sanna, R., Pena, S., Midolo, P., Ng, E.K., Atherton, J.C., Blaser, M.J., Quint, W.G.. Expanding allelic diversity of Helicobacter pylori vacA. J. Clin. Microbiol.. 1998; 36: 2597-2603 [OpenAIRE] [PubMed]

Rhead, J.L., Letley, D.P., Mohammadi, M., Hussein, N., Mohagheghi, M.A., Eshagh Hosseini, M., Atherton, J.C.. A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology. 2007; 133: 926-936 [PubMed] [DOI]

Chung, C., Olivares, A., Torres, E., Yilmaz, O., Cohen, H., Perez-Perez, G.. Diversity of vacA intermediate region among Helicobacter pylori strains from several regions of the world. J. Clin. Microbiol.. 2010; 48: 690-696 [OpenAIRE] [PubMed] [DOI]

Torres, V.J., Ivie, S.E., McClain, M.S., Cover, T.L.. Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin. J. Biol. Chem.. 2005; 280: 21107-21114 [PubMed] [DOI]

Sugimoto, M., Yamaoka, Y.. The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations. Clin. Microbiol. Infect.. 2009; 15: 835-842 [OpenAIRE] [PubMed] [DOI]

Sugimoto, M., Zali, M.R., Yamaoka, Y.. The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the middle east. Eur. J. Clin. Microbiol. Infect. Dis.. 2009; 28: 1227-1236 [OpenAIRE] [PubMed] [DOI]

Kim, I.J., Blanke, S.R.. Remodeling the host environment: Modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (vacA). Front. Cell. Infect. Microbiol.. 2012; 2 [OpenAIRE] [PubMed] [DOI]

69 references, page 1 of 5
Abstract
The Helicobacter pylori vacuolating cytotoxin (VacA) is a secreted pore-forming toxin and a major virulence factor in the pathogenesis of H. pylori infection. While VacA is present in almost all strains, only some forms are toxigenic and pathogenic. While vacA and its genotypes are considered as markers of H. pylori-related diseases or disorders, the pathophysiological mechanisms of VacA and its genotypes remain controversial. This review outlines key findings of publications regarding vacA with emphasis on the relationship between vacA genotypes and the development of human disease.
Subjects
mesheuropmc: bacteriabacterial infections and mycosesdigestive system diseases
free text keywords: vacuolation, R, prolonged Helicobacter pylori infection, Review, VacA genotypes, Medicine, H. pylori-mediated diseases
Funded by
NIH| Regulation of CXC chemokine expression by H. pylori.
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK062813-05
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
69 references, page 1 of 5

Ferreira, R.M., Machado, J.C., Letley, D., Atherton, J.C., Pardo, M.L., Gonzalez, C.A., Carneiro, F., Figueiredo, C.. A novel method for genotyping the Helicobacter pylori vacA intermediate region directly in gastric biopsy specimens. J. Clin. Microbiol.. 2012; 50: 3983-3989 [OpenAIRE] [PubMed] [DOI]

Memon, A.A., Hussein, N.R., Miendje Deyi, V.Y., Burette, A., Atherton, J.C.. Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: A matched case-control study. J. Clin. Microbiol.. 2014; 52: 2984-2989 [OpenAIRE] [PubMed] [DOI]

Shimoyama, T., Yoshimura, T., Mikami, T., Fukuda, S., Crabtree, J.E., Munakata, A.. Evaluation of Helicobacter pylori vacA genotype in Japanese patients with gastric cancer. J. Clin. Pathol.. 1998; 51: 299-301 [OpenAIRE] [PubMed] [DOI]

Cover, T.L., Tummuru, M.K., Cao, P., Thompson, S.A., Blaser, M.J.. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J. Biol. Chem.. 1994; 269: 10566-10573 [PubMed]

Atherton, J.C., Cao, P., Peek, R.M., Tummuru, M.K., Blaser, M.J., Cover, T.L.. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem.. 1995; 270: 17771-17777 [PubMed]

Forsyth, M.H., Atherton, J.C., Blaser, M.J., Cover, T.L.. Heterogeneity in levels of vacuolating cytotoxin gene (vacA) transcription among Helicobacter pylori strains. Infect. Immun.. 1998; 66: 3088-3094 [OpenAIRE] [PubMed]

Letley, D.P., Atherton, J.C.. Natural diversity in the n terminus of the mature vacuolating cytotoxin of Helicobacter pylori determines cytotoxin activity. J. Bacteriol.. 2000; 182: 3278-3280 [OpenAIRE] [PubMed] [DOI]

Strobel, S., Bereswill, S., Balig, P., Allgaier, P., Sonntag, H.G., Kist, M.. Identification and analysis of a new vacA genotype variant of Helicobacter pylori in different patient groups in germany. J. Clin. Microbiol.. 1998; 36: 1285-1289 [OpenAIRE] [PubMed]

Van Doorn, L.J., Figueiredo, C., Sanna, R., Pena, S., Midolo, P., Ng, E.K., Atherton, J.C., Blaser, M.J., Quint, W.G.. Expanding allelic diversity of Helicobacter pylori vacA. J. Clin. Microbiol.. 1998; 36: 2597-2603 [OpenAIRE] [PubMed]

Rhead, J.L., Letley, D.P., Mohammadi, M., Hussein, N., Mohagheghi, M.A., Eshagh Hosseini, M., Atherton, J.C.. A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology. 2007; 133: 926-936 [PubMed] [DOI]

Chung, C., Olivares, A., Torres, E., Yilmaz, O., Cohen, H., Perez-Perez, G.. Diversity of vacA intermediate region among Helicobacter pylori strains from several regions of the world. J. Clin. Microbiol.. 2010; 48: 690-696 [OpenAIRE] [PubMed] [DOI]

Torres, V.J., Ivie, S.E., McClain, M.S., Cover, T.L.. Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin. J. Biol. Chem.. 2005; 280: 21107-21114 [PubMed] [DOI]

Sugimoto, M., Yamaoka, Y.. The association of vacA genotype and Helicobacter pylori-related disease in Latin American and African populations. Clin. Microbiol. Infect.. 2009; 15: 835-842 [OpenAIRE] [PubMed] [DOI]

Sugimoto, M., Zali, M.R., Yamaoka, Y.. The association of vacA genotypes and Helicobacter pylori-related gastroduodenal diseases in the middle east. Eur. J. Clin. Microbiol. Infect. Dis.. 2009; 28: 1227-1236 [OpenAIRE] [PubMed] [DOI]

Kim, I.J., Blanke, S.R.. Remodeling the host environment: Modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (vacA). Front. Cell. Infect. Microbiol.. 2012; 2 [OpenAIRE] [PubMed] [DOI]

69 references, page 1 of 5
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publication . Article . 2016

Relationship between vacA Types and Development of Gastroduodenal Diseases

Tran Thi Huyen Trang; Tran Thanh Binh; Yoshio Yamaoka;