Metabolic Regulation of Histone Acetyltransferases by Endogenous Acyl-CoA Cofactors

Article, Other literature type English OPEN
Montgomery, David C.; Sorum, Alexander W.; Guasch, Laura; Nicklaus, Marc C.; Meier, Jordan L.;
  • Publisher: Elsevier BV
  • Journal: Chemistry & Biology,volume 22,issue 8,pages1,030-1,039 (issn: 1074-5521)
  • Related identifiers: doi: 10.1016/j.chembiol.2015.06.015, pmc: PMC4546520
  • Subject: Molecular Biology | Drug Discovery | Biochemistry | Pharmacology | Molecular Medicine | Clinical Biochemistry | Article

The finding that chromatin modifications are sensitive to changes in cellular cofactor levels potentially links altered tumor cell metabolism and gene expression. However, the specific enzymes and metabolites that connect these two processes remain obscure. Characterizi... View more
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