Screening Bioactives Reveals Nanchangmycin as a Broad Spectrum Antiviral Active against Zika Virus

Article, Other literature type English OPEN
Keiko Rausch; Brent A. Hackett; Nathan L. Weinbren; Sophia M. Reeder; Yoel Sadovsky; Christopher A. Hunter; David C. Schultz; Carolyn B. Coyne; Sara Cherry; (2017)
  • Publisher: Elsevier
  • Journal: Cell Reports,volume 18,issue 3,pages804-815 (issn: 2211-1247)
  • Related identifiers: pmc: PMC5270376, doi: 10.1016/j.celrep.2016.12.068
  • Subject: antivirals | entry | therapeutics | drugs | repurposing | Article | Biology (General) | flavivirus | arbovirus | QH301-705.5
    mesheuropmc: viruses

Zika virus is an emerging arthropod-borne flavivirus for which there are no vaccines or specific therapeutics. We screened a library of 2,000 bioactive compounds for their ability to block Zika virus infection in three distinct cell types with two different strains of Z... View more
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