Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer

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de Heer, Pieter; Sandel, Maro H.; Guertens, Gunther; de Boeck, Gert; Koudijs, Margaretha M.; Nagelkerke, J. Fred; Junggeburt, Jan M. C.; de Bruijn, Ernst A.; van de Velde, Cornelis J. H.; Kuppen, Peter J. K.;
  • Publisher: Springer-Verlag
  • Journal: Cancer chemotherapy and pharmacology, volume 62, issue 5, pages 811-819 (issn: 0344-5704, eissn: 1432-0843)
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  • Identifiers: pmc: PMC2516537, doi: 10.1007/S00280-007-0668-4
  • Subject: Toxicology | Original Article | Immune response | Celecoxib | Pharmacology | Cyclooxygenase-2 | Prostaglandins | Pharmacology (medical) | Cancer Research | Oncology | CC531 rat colon tumor liver metastases model
    mesheuropmc: musculoskeletal diseases

Abstract: Introduction Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce the risk of colorectal cancer in cyclooxygenase-2 (COX-2) overexpressing colorectal cancers. The present study was designed to evaluate the inhibitory effects of the COX-2 inh... View more
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