Artificial Neural Network for the Prediction of Tyrosine-Based Sorting Signal Recognition by Adaptor Complexes

Article English OPEN
Mukherjee, Debarati ; Hanna, Claudia B. ; Aguilar, R. Claudio (2012)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Journal of Biomedicine and Biotechnology, volume 2,012 (issn: 1110-7243, eissn: 1110-7251)
  • Related identifiers: doi: 10.1155/2012/498031, pmc: PMC3312419
  • Subject: Biotechnology | Research Article | T | TP1-1185 | Chemical technology | Technology | Article Subject | TP248.13-248.65

Sorting of transmembrane proteins to various intracellular compartments depends on specific signals present within their cytosolic domains. Among these sorting signals, the tyrosine-based motif (YXXØ) is one of the best characterized and is recognized by μ-subunits of t... View more
  • References (35)
    35 references, page 1 of 4

    Enns, C.. Overview of protein trafficking in the secretory and endocytic pathways. Current Protocols in Cell Biology. 2001; 15: 15.1

    Dacks, J. B., Peden, A. A., Field, M. C.. Evolution of specificity in the eukaryotic endomembrane system. International Journal of Biochemistry and Cell Biology. 2009; 41 (2): 330-340

    Wei, M. L.. Hermansky-Pudlak syndrome: a disease of protein trafficking and organelle function. Pigment Cell Research. 2006; 19 (1): 19-42

    Gruenberg, J., van der Goot, F. G.. Mechanisms of pathogen entry through the endosomal compartments. Nature Reviews Molecular Cell Biology. 2006; 7 (7): 495-504

    Ghosh, P., Kornfeld, S.. The GGA proteins: key players in protein sorting at the trans-Golgi network. European Journal of Cell Biology. 2004; 83 (6): 257-262

    Nakatsu, F., Ohno, H.. Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network. Cell Structure and Function. 2003; 28 (5): 419-429

    Traub, L. M.. Common principles in clathrin-mediated sorting at the Golgi and the plasma membrane. Biochimica et Biophysica Acta. 2005; 1744 (3): 415-437

    Urbanowski, J. L., Piper, R. C.. Ubiquitin sorts proteins into the intralumenal degradative compartment of the late-endosome/vacuole. Traffic. 2001; 2 (9): 622-630

    Bonifacino, J. S., Traub, L. M.. Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annual Review of Biochemistry. 2003; 72: 395-447

    Traub, L. M.. Tickets to ride: selecting cargo for clathrin-regulated internalization. Nature Reviews Molecular Cell Biology. 2009; 10 (9): 583-596

  • Similar Research Results (1)
  • Metrics
    No metrics available
Share - Bookmark