The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity

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Rauckhorst, Adam J.; Gray, Lawrence R.; Sheldon, Ryan D.; Fu, Xiaorong; Pewa, Alvin D.; Feddersen, Charlotte R.; Dupuy, Adam J.; Gibson-Corley, Katherine N.; Cox, James E.; Burgess, Shawn C.; Taylor, Eric B.;
  • Publisher: Elsevier
  • Journal: Molecular Metabolism,volume 6,issue 11,pages1,468-1,479 (issn: 2212-8778, eissn: 2212-8778)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC5681281, doi: 10.1016/j.molmet.2017.09.002
  • Subject: NAFLD, non-alcoholic fatty liver disease | Liver | MPC, mitochondrial pyruvate carrier | Internal medicine | Mitochondrial pyruvate carrier (MPC) | HFD, high fat diet | Gluconeogenesis | HOMA-IR, homeostatic model assessment of insulin resistance | TCA, tricarboxylic acid cycle | Original Article | NASH, non-alcoholic steatohepatitis | Inflammation | T2D, type 2 diabetes | Fibrosis | RC31-1245 | NCD, normal chow diet | Diabetes | ITT, insulin tolerance test
    mesheuropmc: nutritional and metabolic diseases | immune system diseases | digestive, oral, and skin physiology

Objective: Excessive hepatic gluconeogenesis is a defining feature of type 2 diabetes (T2D). Most gluconeogenic flux is routed through mitochondria. The mitochondrial pyruvate carrier (MPC) transports pyruvate from the cytosol into the mitochondrial matrix, thereby gati... View more