Increased PDGFRα Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis

Article, Other literature type English OPEN
Olson, Lorin E.; Soriano, Philippe;

PDGF signaling regulates the development of mesenchymal cell types in the embryo and in the adult, but the role of receptor activation in tissue homeostasis has not been investigated. We have generated conditional knockin mice with mutations in PDGFRα that drive increas... View more
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