pVAC-Seq: A genome-guided in silico approach to identifying tumor neoantigens

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Hundal, Jasreet; Carreno, Beatriz M.; Petti, Allegra A.; Linette, Gerald P.; Griffith, Obi L.; Mardis, Elaine R.; Griffith, Malachi;
(2016)

Cancer immunotherapy has gained significant momentum from recent clinical successes of checkpoint blockade inhibition. Massively parallel sequence analysis suggests a connection between mutational load and response to this class of therapy. Methods to identify which tum... View more