H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S?

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MA, Kaium; Liu, Yan; Zhu, Qing; Liu, Chun-hua; Duan, Jun-Li; Tan, Benny K-H.; Zhu, Yi Zhun;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 6,issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1371/journal.pone.0020525, pmc: PMC3124470
  • Subject: Cancer Treatment | Biotechnology | Animal Models | Research Article | Biology | Molecular Cell Biology | Cell Death | Gastric Cancer | Medicine | Drug Research and Development | Basic Cancer Research | Oncology | Mouse | Q | R | Drug Discovery | Model Organisms | Drugs and Devices | Gastrointestinal Tumors | Biochemistry | Science | Cancers and Neoplasms

BACKGROUND: S-propargyl-cysteine (SPRC), an H(2)S donor, is a structural analogue of S-allycysteine (SAC). It was investigated for its potential anti-cancer effect on SGC-7901 gastric cancer cells and the possible mechanisms that may be involved. METHODS AND FINDINGS: S... View more
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