publication . Article . 2014

Comparison of several sequence-based association methods in pedigrees

Mathew, George; George, Varghese; Xu, Hongyan;
Open Access
  • Published: 01 Jun 2014 Journal: BMC Proceedings, volume 8 (eissn: 1753-6561, Copyright policy)
  • Publisher: Springer Science and Business Media LLC
Abstract
Genome-wide association studies are very powerful in determining the genetic variants affecting complex diseases. Most of the available methods are very useful in detecting association between common variants and complex diseases. Recently, methods to detect rare variants in association with complex diseases have been developed with the increasingly available sequencing data from next-generation sequencing. In this paper, we evaluate and compare several of these recent methods for performing statistical association using whole genome sequencing data in pedigrees. Specifically, functional principal component analysis (FPCA), extended combined multivariate and col...
Subjects
free text keywords: General Biochemistry, Genetics and Molecular Biology, General Medicine, Multivariate statistics, Medicine, business.industry, business, Genetic analysis, Bioinformatics, Pedigree chart, Correlation and dependence, Genetic variants, Functional principal component analysis, Whole genome sequencing, Genetic association, Proceedings
Funded by
NIH| Identifying T2D Variants by DNA Sequencing in Multiethnic Samples
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01DK085584-01
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Identification and Replication of Type 2 Diabetes Genes in Mexican Americans
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01DK085501-02
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Identifying variants causal for Type 2 Diabetes in Major human populations
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01DK085545-02
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| GENETICS OF GALLBLADDER DISEASE IN MEXICAN AMERICANS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01DK053889-04
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
,
NIH| Multiethnic Study of Type 2 Diabetes Genes
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5U01DK085526-05
  • Funding stream: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

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