Methylphenidate Attenuates Limbic Brain Inhibition after Cocaine-Cues Exposure in Cocaine Abusers

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Volkow, Nora D. ; Wang, Gene-Jack ; Tomasi, Dardo ; Telang, Frank ; Fowler, Joanna S. ; Pradhan, Kith ; Jayne, Millard ; Logan, Jean ; Goldstein, Rita Z. ; Alia-Klein, Nelly ; Wong, Christopher (2010)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 5, issue 7 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC2901385, doi: 10.1371/journal.pone.0011509
  • Subject: Q | R | Research Article | Neuroscience | Science | Neuroscience/Behavioral Neuroscience | Medicine | Neuroscience/Cognitive Neuroscience

Dopamine (phasic release) is implicated in conditioned responses. Imaging studies in cocaine abusers show decreases in striatal dopamine levels, which we hypothesize may enhance conditioned responses since tonic dopamine levels modulate phasic dopamine release. To test ... View more
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