Response of methicillin-resistant Staphylococcus aureus to amicoumacin A.

Article English OPEN
Amrita Lama; Jan Pané-Farré; Tai Chon; Anna M Wiersma; Clarissa S Sit; John C Vederas; Michael Hecker; Michiko M Nakano;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE,volume 7,issue 3 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC3316591, doi: 10.1371/journal.pone.0034037
  • Subject: Research Article | Biology | Infectious Diseases | Microbiology | Medicine | Bacterial Pathogens | Bacterial Diseases | Q | Bacteriology | R | Genetics | Science | Genomics

Amicoumacin A exhibits strong antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), hence we sought to uncover its mechanism of action. Genome-wide transcriptome analysis of S. aureus COL in response to amicoumacin A showed alteration in tra... View more
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