Targeted Delivery of siRNA to Macrophages for Anti-inflammatory Treatment

Article, Other literature type English OPEN
Kim, Sang-Soo ; Ye, Chunting ; Kumar, Priti ; Chiu, Isaac ; Subramanya, Sandesh ; Wu, Haoquan ; Shankar, Premlata ; Manjunath, N (2010)
  • Publisher: Nature Publishing Group
  • Journal: Molecular Therapy, volume 18, issue 5, pages 993-1,001 (issn: 1525-0016)
  • Related identifiers: doi: 10.1038/mt.2010.27, pmc: PMC2890121
  • Subject: Molecular Biology | Genetics | Drug Discovery | Pharmacology | Original Articles | Molecular Medicine

Inflammation mediated by tumor necrosis factor-α (TNF-α) and the associated neuronal apoptosis characterizes a number of neurologic disorders. Macrophages and microglial cells are believed to be the major source of TNF-α in the central nervous system (CNS). Here, we sho... View more
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