publication . Article . 2016

Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals

Leay-Kiaw Er; Semon Wu; Hsin-Hua Chou; Lung-An Hsu; Ming-Sheng Teng; Yu-Chen Sun; Yu-Lin Ko;
Open Access English
  • Published: 01 Mar 2016 Journal: PLoS ONE, volume 11, issue 3 (issn: 1932-6203, eissn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science
Abstract
BACKGROUND:Insulin resistance (IR) and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which contribute to the development of diabetes mellitus and cardiovascular diseases. We compared traditional lipid levels and ratios and combined them with fasting plasma glucose (FPG) levels or adiposity status for determining their efficiency as independent risk factors for IR. METHODS:We enrolled 511 Taiwanese individuals for the analysis. The clinical usefulness of various parameters--such as traditional lipid levels and ratios; visceral adiposity indicators, visceral adiposity index (VAI), and lipid accumulat...
Subjects
mesheuropmc: nutritional and metabolic diseases
free text keywords: Adiponectin, Lipids, Research Article, Insulin, Hormones, Body Weight, Molecular Development, Immune System, Cholesterol, Cytokines, Adipokines, Immunology, Obesity, Biology and Life Sciences, Immune Physiology, Developmental Biology, Body Mass Index, Physiology, Medicine, Leptin, Innate Immune System, Q, R, Peptide Hormones, Physiological Parameters, Science, Biochemistry, Medicine and Health Sciences, Diabetic Endocrinology, Endocrinology
38 references, page 1 of 3

1 Matthaei S, Stumvoll M, Kellerer M, Haring HU. Pathophysiology and pharmacological treatment of insulin resistan ce. Endocr Rev. 2000; 21:585–618. 11133066 [PubMed]

2 Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, et al Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med. 1993; 329:1988–1992. 8247074 [PubMed]

3 DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979; 237:E214–E223. 382871 [PubMed]

4 Simental-Mendia LE, Rodriguez-Moran M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. MetabSyndrRelatDisord. 2008; 6:299–304. 19067533 [PubMed]

5 Guerrero-Romero F, Simental-Mendia LE, Gonzalez-Ortiz M, Martinez-Abundis E, Ramos-Zavala MG, Hernandez-Gonzalez SO, et al The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemichyperinsulinemic clamp. J ClinEndocrinolMetab. 2010; 95:3347–3351. 20484475 [PubMed]

6 Du T, Yuan G, Zhang M, Zhou X, Sun X, Yu X. Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance. Cardiovascular Diabetology. 2014; 13:146 146–155. 25326814 [OpenAIRE] [PubMed]

7 Vasques AC, Novaes FS, de Oliveira Mda S, Souza JR, Yamanaka A, Pareja JC, et al TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study. Diabetes Res Clin Pract. 2011; 93:e98–e100. doi: 10.1016/j.diabres.2011.05.030 21665314 [OpenAIRE] [PubMed]

8 Lee SH, Han K, Yang HK, Kim MK, Yoon KH, Kwon HS, et al Identifying subgroups of obesity using the produc t of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010. ClinEndocrinol (Oxf). 2014; 82:213–20. 24841432 [PubMed]

9 Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, et al Visceral adiposity index. A reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 2010; 33:920–922. doi: 10.2337/dc09-1825 20067971 [OpenAIRE] [PubMed]

10 Ciresi A, Amato MC, Pizzolanti G, Giordano Galluzzo C. Visceral adiposity index is associated with insulin sensitivity and adipocytokine levels in newly diagnosed acromegalic patients. J ClinEndocrinolMetab. 2012; 97:2907–2915. 22679062 [OpenAIRE] [PubMed]

11 Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006; 444: 840–846. 17167471 [PubMed]

12 Ioachimescu AG, Brennan DM, Hoar BM, Hoogwerf BJ. The lipid accumulation product and all-cause mortality in patients at high cardiovascular risk: a PreCIS Database Study. Obesity. 2010; 18:1836–1844. doi: 10.1038/oby.2009.453 20035284 [PubMed]

13 Teng MS, Hsu LA, Wu S, Sun YC, Juan SH, Ko YL. Association of CDH13 Genotypes/Haplotypes with Circulating Adiponectin Levels, Metabolic Syndrome, and Related Metabolic Phenotypes: The Role of the Suppression Effect. PLoS One. 2015; 10:e0122664 doi: 10.1371/journal.pone.0122664 25875811 [OpenAIRE] [PubMed]

14 Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000; 23:57–63. 10857969 [PubMed]

15 Wu TL, Chen Tsai, Chang PY, Tsao KC, Sun CF, Wu LL, et al Establishment of an in-house ELISA and the reference range for serum amyloid A (SAA): complementarity between SAA and C-reactive protein as markers of inflammation. ClinChimActa. 2007; 376:72–6. 16916504 [PubMed]

38 references, page 1 of 3
Abstract
BACKGROUND:Insulin resistance (IR) and the consequences of compensatory hyperinsulinemia are pathogenic factors for a set of metabolic abnormalities, which contribute to the development of diabetes mellitus and cardiovascular diseases. We compared traditional lipid levels and ratios and combined them with fasting plasma glucose (FPG) levels or adiposity status for determining their efficiency as independent risk factors for IR. METHODS:We enrolled 511 Taiwanese individuals for the analysis. The clinical usefulness of various parameters--such as traditional lipid levels and ratios; visceral adiposity indicators, visceral adiposity index (VAI), and lipid accumulat...
Subjects
mesheuropmc: nutritional and metabolic diseases
free text keywords: Adiponectin, Lipids, Research Article, Insulin, Hormones, Body Weight, Molecular Development, Immune System, Cholesterol, Cytokines, Adipokines, Immunology, Obesity, Biology and Life Sciences, Immune Physiology, Developmental Biology, Body Mass Index, Physiology, Medicine, Leptin, Innate Immune System, Q, R, Peptide Hormones, Physiological Parameters, Science, Biochemistry, Medicine and Health Sciences, Diabetic Endocrinology, Endocrinology
38 references, page 1 of 3

1 Matthaei S, Stumvoll M, Kellerer M, Haring HU. Pathophysiology and pharmacological treatment of insulin resistan ce. Endocr Rev. 2000; 21:585–618. 11133066 [PubMed]

2 Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, et al Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med. 1993; 329:1988–1992. 8247074 [PubMed]

3 DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979; 237:E214–E223. 382871 [PubMed]

4 Simental-Mendia LE, Rodriguez-Moran M, Guerrero-Romero F. The product of fasting glucose and triglycerides as surrogate for identifying insulin resistance in apparently healthy subjects. MetabSyndrRelatDisord. 2008; 6:299–304. 19067533 [PubMed]

5 Guerrero-Romero F, Simental-Mendia LE, Gonzalez-Ortiz M, Martinez-Abundis E, Ramos-Zavala MG, Hernandez-Gonzalez SO, et al The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemichyperinsulinemic clamp. J ClinEndocrinolMetab. 2010; 95:3347–3351. 20484475 [PubMed]

6 Du T, Yuan G, Zhang M, Zhou X, Sun X, Yu X. Clinical usefulness of lipid ratios, visceral adiposity indicators, and the triglycerides and glucose index as risk markers of insulin resistance. Cardiovascular Diabetology. 2014; 13:146 146–155. 25326814 [OpenAIRE] [PubMed]

7 Vasques AC, Novaes FS, de Oliveira Mda S, Souza JR, Yamanaka A, Pareja JC, et al TyG index performs better than HOMA in a Brazilian population: a hyperglycemic clamp validated study. Diabetes Res Clin Pract. 2011; 93:e98–e100. doi: 10.1016/j.diabres.2011.05.030 21665314 [OpenAIRE] [PubMed]

8 Lee SH, Han K, Yang HK, Kim MK, Yoon KH, Kwon HS, et al Identifying subgroups of obesity using the produc t of triglycerides and glucose: the Korea National Health and Nutrition Examination Survey, 2008–2010. ClinEndocrinol (Oxf). 2014; 82:213–20. 24841432 [PubMed]

9 Amato MC, Giordano C, Galia M, Criscimanna A, Vitabile S, Midiri M, et al Visceral adiposity index. A reliable indicator of visceral fat function associated with cardiometabolic risk. Diabetes Care. 2010; 33:920–922. doi: 10.2337/dc09-1825 20067971 [OpenAIRE] [PubMed]

10 Ciresi A, Amato MC, Pizzolanti G, Giordano Galluzzo C. Visceral adiposity index is associated with insulin sensitivity and adipocytokine levels in newly diagnosed acromegalic patients. J ClinEndocrinolMetab. 2012; 97:2907–2915. 22679062 [OpenAIRE] [PubMed]

11 Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006; 444: 840–846. 17167471 [PubMed]

12 Ioachimescu AG, Brennan DM, Hoar BM, Hoogwerf BJ. The lipid accumulation product and all-cause mortality in patients at high cardiovascular risk: a PreCIS Database Study. Obesity. 2010; 18:1836–1844. doi: 10.1038/oby.2009.453 20035284 [PubMed]

13 Teng MS, Hsu LA, Wu S, Sun YC, Juan SH, Ko YL. Association of CDH13 Genotypes/Haplotypes with Circulating Adiponectin Levels, Metabolic Syndrome, and Related Metabolic Phenotypes: The Role of the Suppression Effect. PLoS One. 2015; 10:e0122664 doi: 10.1371/journal.pone.0122664 25875811 [OpenAIRE] [PubMed]

14 Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care. 2000; 23:57–63. 10857969 [PubMed]

15 Wu TL, Chen Tsai, Chang PY, Tsao KC, Sun CF, Wu LL, et al Establishment of an in-house ELISA and the reference range for serum amyloid A (SAA): complementarity between SAA and C-reactive protein as markers of inflammation. ClinChimActa. 2007; 376:72–6. 16916504 [PubMed]

38 references, page 1 of 3
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publication . Article . 2016

Triglyceride Glucose-Body Mass Index Is a Simple and Clinically Useful Surrogate Marker for Insulin Resistance in Nondiabetic Individuals

Leay-Kiaw Er; Semon Wu; Hsin-Hua Chou; Lung-An Hsu; Ming-Sheng Teng; Yu-Chen Sun; Yu-Lin Ko;