Infusing Sodium Bicarbonate Suppresses Hydrogen Peroxide Accumulation and Superoxide Dismutase Activity in Hypoxic-Reoxygenated Newborn Piglets

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Liu, Jiang-Qin ; Manouchehri, Namdar ; Lee, Tze-Fun ; Yao, Mingzhu ; Bigam, David L. ; Cheung, Po-Yin (2012)
  • Publisher: Public Library of Science
  • Journal: PLoS ONE, volume 7, issue 6 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: doi: 10.1371/journal.pone.0039081, pmc: PMC3382246
  • Subject: Neurointensive Care | Animal Models | Signaling Cascades | Cellular Stress Responses | Research Article | Biology | Molecular Cell Biology | Signal Transduction | Enzymes | Medicine | Critical Care and Emergency Medicine | Q | R | Neonatology | Model Organisms | Stress Signaling Cascade | Science | Biochemistry | Pediatrics | Resuscitation | Metabolism

Background The effectiveness of sodium bicarbonate (SB) has recently been questioned although it is often used to correct metabolic acidosis of neonates. The aim of the present study was to examine its effect on hemodynamic changes and hydrogen peroxide (H2O2) generatio... View more
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