Heme Signaling Impacts Global Gene Expression, Immunity and Dengue Virus Infectivity in Aedes aegypti.

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Vanessa Bottino-Rojas ; Octávio A C Talyuli ; Natapong Jupatanakul ; Shuzhen Sim ; George Dimopoulos ; Thiago M Venancio ; Ana C Bahia ; Marcos H Sorgine ; Pedro L Oliveira ; Gabriela O Paiva-Silva
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS ONE, volume 10, issue 8 (issn: 1932-6203, eissn: 1932-6203)
  • Related identifiers: pmc: PMC4537099, doi: 10.1371/journal.pone.0135985
  • Subject: Q | R | Research Article | Science | Medicine

Blood-feeding mosquitoes are exposed to high levels of heme, the product of hemoglobin degradation. Heme is a pro-oxidant that influences a variety of cellular processes. We performed a global analysis of heme-regulated Aedes aegypti (yellow fever mosquito) transcriptio... View more