Utility and limitations of Spa-typing in understanding the epidemiology of staphylococcus aureus bacteraemia isolates in a single University Hospital

Article English OPEN
Satta, Giovanni; Ling, Clare Louise; Cunningham, Emma Shelley; McHugh, Timothy Daniel; Hopkins, Susan;
(2013)

Background Staphylococcus aureus (SA) is a recognized cause of nosocomial infections with 8,767 SA bacteraemia (SAB) cases reported in England only in 2012. Different typing methods have been developed but they are not generally performed as a routine investigation in h... View more
  • References (12)
    12 references, page 1 of 2

    1. HPA report “mandatory surveillance of MSSA bacteraemia - April 2011/march 2012. HPA.org.uk (updated: 22 May 2013).

    2. Lamagni TL, Potz N, Powell D, Pebody R, Wilson J, Duckworth G: Mortality in patients with meticillin-resistant staphylococcus aureus bacteraemia, England 2004-2005. J Hosp Infect 2011, 77(1):16-20.

    3. Thwaites GE and United Kingdom Clinical Infection Research Group (UKCIRG): The management of staphylococcus aureus bacteremia in the United Kingdom and Vietnam: a multi-centre evaluation. PLoS One 2010, 5(12):e14170.

    4. Vainio A, Koskela S, Virolainen A, Vuopio J, Salmenlinna S: Adapting spa typing for national laboratory-based surveillance of methicillin-resistant staphylococcus aureus. Eur J Clin Microbiol Infect Dis 2011, 30(6):789-797.

    5. Petersson AC, Olsson-Liljequist B, Miörner H, Haeggman S: Evaluating the usefulness of spa typing, in comparison with pulsed-field gel electrophoresis, for epidemiological typing of methicillin-resistant staphylococcus aureus in a low-prevalence region in Sweden 2000- 2004. Clin Microbiol Infect 2010, 16(5):456-462.

    6. Koreen L, Ramaswamy SV, Graviss EA, Naidich S, Musser JM, Kreiswirth BN: Spa typing method for discriminating among staphylococcus aureus isolates: implications for use of a single marker to detect genetic microand macrovariation. J Clin Microbiol 2004, 42:792-799.

    7. Shopsin B, Gomez M, Montgomery SO, Smith DH, Waddington M, Dodge DE, Bost DA, Riehman M, Naidich S, Kreiswirth BN: Evaluation of protein a gene polymorphic region DNA sequencing for typing of staphylococcus aureus strains. J Clin Microbiol 1999, 37:3556-3563.

    8. Enright MC, Spratt BG: Multilocus sequence typing. Trends Microbiol 1999, 7:482-487.

    9. Sabat AJ, Budimir A, Nashev D, Sá-Leão R, Van Dijl J, Laurent F, Grundmann H, Friedrich AW, ESCMID Study Group of Epidemiological Markers (ESGEM): Overview of molecular typing methods for outbreak detection and epidemiological surveillance. Euro Surveill 2013, 18(4):20380.

    10. Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, Friedrich AW, European Staphylococcal Reference Laboratory Working Group: Geographic distribution of staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis. PLoS Med 2010, 7(1):e1000215.

  • Related Research Results (2)
  • Related Organizations (4)
  • Metrics
Share - Bookmark