Senescence-Associated Molecular and Epigenetic Alterations in Mesenchymal Stem Cell Cultures from Amniotic Fluid of Normal and Fetus-Affected Pregnancy

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Savickienė, Jūratė ; Baronaitė, Sandra ; Zentelytė, Aistė ; Treigytė, Gražina ; Navakauskienė, Rūta (2016)
  • Publisher: Hindawi Publishing Corporation
  • Journal: Stem Cells International, volume 2,016 (issn: 1687-966X, eissn: 1687-9678)
  • Related identifiers: pmc: PMC5075644, doi: 10.1155/2016/2019498
  • Subject: Research Article | Internal medicine | amniotic fluid ; mesenchymal stem cells ; epigenetics | RC31-1245 | Article Subject
    mesheuropmc: embryonic structures

Human amniotic-fluid-derived mesenchymal stem cells (AF-MSCs) are interesting for their multilineage differentiation potential and wide range of therapeutic applications due to the ease of culture expansion. However, MSCs undergo replicative senescence. So far, the mole... View more
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