Characterization of the genetic variation present in CYP3A4 in three South African populations
Britt Ingrid Drögemöller; Marieth ePlummer; Lundi eKorkie; Gloudi eAgenbag; Anke eDunaiski; Dana eNiehaus; Liezl eKoen; Stefan eGebhardt; Nicol eSchneider; Antonel eOlckers; Galen eWright; Louise eWarnich;
Publisher: Frontiers Media S.A.
Journal: Frontiers in Genetics,volume 4 (issn: 1664-8021, eissn: 1664-8021)
Subject: CYP3A4 | QH426-470 | mixed ancestry | Genetics | Xhosa | Pharmacology | Original Research Article | Khoisan | South African populations | pharmacogenetics
TThe CYP3A4 enzyme is the most abundant human cytochrome P450 and is regarded as the most important enzyme involved in drug metabolism. Inter-individual and inter-population variability in gene expression and enzyme activity are thought to be influenced, in part, by gen... View more