A bacterial regulatory RNA attenuates virulence, spread and human host cell phagocytosis.

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Le Pabic, Hélène; Germain-Amiot, Noëlla; Bordeau, Valérie; Felden, Brice;
  • Publisher: Oxford University Press
  • Journal: Nucleic Acids Research,volume 43,issue 19,pages9,232-9,248 (issn: 0305-1048, eissn: 1362-4962)
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  • Related identifiers: doi: 10.1093/nar/gkv783, pmc: PMC4627067
  • Subject: [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology | Gene regulation, Chromatin and Epigenetics | [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology

International audience; Staphylococcus aureus pathogenesis is directed by regulatory proteins and RNAs. We report the case of an RNA attenuating virulence and host uptake, possibly to sustain commensalism. A S. aureus sRNA, SprC (srn 3610), reduced virulence and bacteri... View more
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