Molecular recognition of AT-DNA sequences by the induced CD pattern of dibenzotetraaza[14]annulene (DBTAA)–adenine derivatives

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Radić Stojković, Marijana; Škugor, Marko; Dudek, Łukasz; Grolik, Jarosław; Eilmes, Julita; Piantanida, Ivo;
(2014)
  • Publisher: Beilstein-Institut
  • Journal: Beilstein Journal of Organic Chemistry,volume 10,pages2,175-2,185 (issn: 1860-5397, eissn: 1860-5397)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.3762/bjoc.10.225, pmc: PMC4168902
  • Subject: Chemistry | Full Research Paper | Q | DBTAA-adenine conjugate | Organic chemistry | QD241-441 | Science | ds-DNA/RNA | nucleic acids | circular dichroism | AT-DNA recognition | minor groove binding

Summary An investigation of the interactions of two novel and several known DBTAA–adenine conjugates with double-stranded DNA and RNA has revealed the DNA/RNA groove as the dominant binding site, which is in contrast to the majority of previously studied DBTAA analogues... View more
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