A germline FANCA alteration that is associated with increased sensitivity to DNA damaging agents

Article English OPEN
Wilkes, David C.; Sailer, Verena; Xue, Hui; Cheng, Hongwei; Collins, Colin C.; Gleave, Martin; Wang, Yuzhuo; Demichelis, Francesca; Beltran, Himisha; Rubin, Mark A.; Rickman, David S.;
(2017)
  • Publisher: Cold Spring Harbor Laboratory Press
  • Journal: Cold Spring Harbor Molecular Case Studies,volume 3,issue 5 (eissn: 2373-2873)
  • Related identifiers: doi: 10.7892/boris.110751, doi: 10.1101/mcs.a001487, pmc: PMC5593159
  • Subject: prostate cancer | Research Article | 500 Science | 570 Life sciences; biology
    mesheuropmc: hemic and lymphatic diseases | congenital, hereditary, and neonatal diseases and abnormalities | nutritional and metabolic diseases

Defects in genes involved in DNA damage repair (DDR) pathway are emerging as novel biomarkers and targets for new prostate cancer drug therapies. A previous report revealed an association between an exceptional response to cisplatin treatment and a somatic loss of heter... View more
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