Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation

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Guthikonda, Kranthi; Zhang, Hongmei; Nolan, Vikki G.; Soto-Ramírez, Nelís; Ziyab, Ali H.; Ewart, Susan; Arshad, Hasan S.; Patil, Veeresh; Holloway, John W.; Lockett, Gabrielle A.; Karmaus, Wilfried;

Background: The prevalence of asthma in girls increases after puberty. Previous studies have detected associations between sex hormones and asthma, as well as between sex hormones and T helper 2 (Th2) asthma-typical immune responses. Therefore, we hypothesized that exog... View more