Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation

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Guthikonda, Kranthi ; Zhang, Hongmei ; Nolan, Vikki G ; Soto-Ramírez, Nelís ; Ziyab, Ali H ; Ewart, Susan ; Arshad, Hasan S ; Patil, Veeresh ; Holloway, John W ; Lockett, Gabrielle A ; Karmaus, Wilfried (2014)
  • Publisher: BioMed Central
  • Journal: Clinical Epigenetics, volume 6, issue 1, pages 17-17 (issn: 1868-7075, eissn: 1868-7083)
  • Related identifiers: doi: 10.1186/1868-7083-6-17, pmc: PMC4171400
  • Subject: GATA3 gene | DNA methylation | genetic variants | oral contraceptives | single nucleotide polymorphism | adolescence | asthma | puberty | CpG | age at menarche | Research | epigenetics

Background: The prevalence of asthma in girls increases after puberty. Previous studies have detected associations between sex hormones and asthma, as well as between sex hormones and T helper 2 (Th2) asthma-typical immune responses. Therefore, we hypothesized that exog... View more