Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level
- Publisher: Springer International Publishing
(issn: 2193-1801, eissn: 2193-1801)
Cell- and tissue-based therapy | Senescence | Prelamin A | Multidisciplinary | Lamin A | Mesenchymal stem cells | Short Report
Background Human mesenchymal stem cells (MSC), during in vitro expansion, undergo a progressive loss of proliferative potential that leads to the senescent state, associated with a reduction of their “medicinal” properties. This may hampers their efficacy in the treatme...