Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level

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Bellotti, Chiara ; Capanni, Cristina ; Lattanzi, Giovanna ; Donati, Davide ; Lucarelli, Enrico ; Duchi, Serena (2016)

Background Human mesenchymal stem cells (MSC), during in vitro expansion, undergo a progressive loss of proliferative potential that leads to the senescent state, associated with a reduction of their “medicinal” properties. This may hampers their efficacy in the treatme... View more
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