Progress in developing cationic vectors for non-viral systemic gene therapy against cancer.

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Morille, Marie ; Passirani, Catherine ; Vonarbourg, Arnaud ; Clavreul, Anne ; Benoit, Jean-Pierre (2008)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/j.biomaterials.2008.04.036
  • Subject: [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases | MESH: Lipids | MESH : Genetic Vectors | MESH : Polymers | MESH : Cations | MESH : Models, Theoretical | [ SDV.MHEP.ME ] Life Sciences [q-bio]/Human health and pathology/Emerging diseases | MESH: Humans | MESH : Lipids | MESH: Models, Theoretical | MESH: Molecular Structure | MESH: Cations | MESH: Gene Therapy | MESH : Molecular Structure | MESH : Gene Therapy | MESH : Humans | MESH: Neoplasms | MESH: Genetic Vectors | MESH: Polymers | MESH : Neoplasms

International audience; Initially, gene therapy was viewed as an approach for treating hereditary diseases, but its potential role in the treatment of acquired diseases such as cancer is now widely recognized. The understanding of the molecular mechanisms involved in ca... View more
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    3.1 - Barriers to systemic gene delivery ........................................................................................... 14 3.2 - Barriers to intracellular trafficking in gene delivery ................................................................. 16 4.1.4 - Solutions to the limitations of PEG coating ....................................................................... 33

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