The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles

Article, Preprint English OPEN
Topalidou, Irini; Cattin-Ortolá, Jérôme; Pappas, Andrea L.; Cooper, Kirsten; Merrihew, Gennifer E.; MacCoss, Michael J.; Ailion, Michael;
(2016)
  • Publisher: Public Library of Science
  • Journal: PLoS Genetics, volume 12, issue 5 (issn: 1553-7390, eissn: 1553-7404)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC4871572, doi: 10.1371/journal.pgen.1006074, doi: 10.1101/046003
  • Subject: Caenorhabditis | Animal Models | Research Article | Fluorescence Imaging | Biomechanics | Neurons | Vesicles | QH426-470 | Genetics | Biosynthesis | Animals | Motor Neurons | Biological Locomotion | Cellular Types | Biology and Life Sciences | Neuroscience | Research and Analysis Methods | Nematoda | bepress|Life Sciences|Cell and Developmental Biology|Cell Biology | Physiology | Animal Cells | Caenorhabditis Elegans | Cellular Neuroscience | bepress|Life Sciences|Biology | Cell Biology | Phenotypes | Imaging Techniques | Model Organisms | Cellular Structures and Organelles | Biochemistry | Organisms | Medicine and Health Sciences | Invertebrates

The dense-core vesicle is a secretory organelle that mediates the regulated release of peptide hormones, growth factors, and biogenic amines. Dense-core vesicles originate from the trans-Golgi of neurons and neuroendocrine cells, but it is unclear how this specialized o... View more