publication . Other literature type . Article . 2016

PET Imaging of Extracellular pH in Tumors with 64Cu- and 18F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study

Jason Lewis; Nerissa Viola; Linden Wyatt; Mirkka P Sarparanta;
Open Access
  • Published: 21 Jul 2016
  • Publisher: American Chemical Society (ACS)
Abstract
pH (low) insertion peptides (pHLIP peptides) target acidic extracellular environments in vivo due to pH-dependent cellular membrane insertion. Two variants (Var3 and Var7) and wild-type (WT) pHLIP peptides have shown promise for in vivo imaging of breast cancer. Two positron emitting radionuclides (64Cu and 18F) were used to label the NOTA- and NO2A-derivatized Var3, Var7, and WT peptides for in vivo biodistribution studies in 4T1 orthotopic tumor-bearing BALB/c mice. All of the constructs were radiolabeled with 64Cu or [18F]-AlF in good yield. The in vivo biodistribution of the 12 constructs in 4T1 orthotopic allografted female BALB/c mice indicated that NO2A-c...
Subjects
free text keywords: Biotechnology, Organic Chemistry, Bioengineering, Pharmacology, Pharmaceutical Science, Biomedical Engineering
Funded by
NIH| pHLIP-based agents for pre-, intra-, and post-operative imaging and therapy of br
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1F32CA186721-01A1
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Shared Instrument: Focus microPET
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1S10RR020892-01
  • Funding stream: NATIONAL CENTER FOR RESEARCH RESOURCES
,
NIH| MOUSE GENETICS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 2P30CA008748-43
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| PET Imaging of Cancer with pH (Low) Insertion Peptide (pHLIP)
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA138468-04
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| The Ivis Spectrum CT for Pre-Clinical Oncology Research
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1S10OD016207-01
  • Funding stream: OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH
22 references, page 1 of 2

Cairns R.; Papandreou I.; Denko N. (2006) Overcoming physiologic barriers to cancer treatment by molecularly targeting the tumor microenvironment. Mol. Cancer Res. 4, 61–70. 10.1158/1541-7786.MCR-06-0002.16513837 [PubMed] [DOI]

Gatenby R. A.; Gillies R. J. (2004) Why do cancers have high aerobic glycolysis?. Nat. Rev. Cancer 4, 891–899. 10.1038/nrc1478.15516961 [OpenAIRE] [PubMed] [DOI]

Griffiths J. R., McIntyre D. J. O., Howe F. A., and Stubbs M. (2001) Why are cancer acidic? A carrier-mediated diffusion for H+ transport in the interstitial fluid, In The Tumor Microenvironment: Causes and Consequences of Hypoxia and Acidity (Gillies R. J., Ed.) pp 46–62, Vol. 240, Novartis Foundation Symposia, John Wiley and Sons, Chichester.

Andreev O. A.; Engelman D. M.; Reshetnyak Y. K. (2010) PH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol. Membr. Biol. 27, 341–352. 10.3109/09687688.2010.509285.20939768 [OpenAIRE] [PubMed] [DOI]

Andreev O. A., Engelman D. M., and Reshetnyak Y. K. (2014) Targeting diseased tissues by pHLIP insertion at low cell surface pH. Front. Physiol.5, DOI: 10.3389/fphys.2014.00097. [OpenAIRE] [DOI]

Andreev O. A.; Dupuy A. D.; Segala M.; Sandugu S.; Serra D. A.; Chichester C. O.; Engelman D. M.; Reshetnyak Y. K. (2007) Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc. Natl. Acad. Sci. U. S. A. 104, 7893–7898. 10.1073/pnas.0702439104.17483464 [OpenAIRE] [PubMed] [DOI]

Viola-Villegas N.; Divilov V.; Andreev O.; Reshetnyak Y.; Lewis J. (2012) Towards the improvement of an acidosis-targeting peptide PET tracer. J. Nucl. Med. 53, 1673.

Yao L.; Daniels J.; Wijesinghe D.; Andreev O. A.; Reshetnyak Y. K. (2013) PHLIP®-mediated delivery of PEGylated liposomes to cancer cells. J. Controlled Release 167, 228–237. 10.1016/j.jconrel.2013.01.037. [OpenAIRE] [DOI]

Yao L.; Daniels J.; Moshnikova A.; Kuznetsov S.; Ahmed A.; Engelman D. M.; Reshetnyak Y. K.; Andreev O. A. (2013) pHLIP peptide targets nanogold particles to tumors. Proc. Natl. Acad. Sci. U. S. A. 110, 465–470. 10.1073/pnas.1219665110.23267062 [OpenAIRE] [PubMed] [DOI]

Vavere A. L.; Biddlecombe G. B.; Spees W. M.; Garbow J. R.; Wijesinghe D.; Andreev O. A.; Engelman D. M.; Reshetnyak Y. K.; Lewis J. S. (2009) A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res. 69, 4510–4516. 10.1158/0008-5472.CAN-08-3781.19417132 [OpenAIRE] [PubMed] [DOI]

Daumar P.; Wanger-Baumann C. A.; Pillarsetty N.; Fabrizio L.; Carlin S. D.; Andreev O. A.; Reshetnyak Y. K.; Lewis J. S. (2012) Efficient 18 F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjugate Chem. 23, 1557–1566. 10.1021/bc3000222. [OpenAIRE] [DOI]

Viola-Villegas N. T.; Carlin S. D.; Ackerstaff E.; Sevak K. K.; Divilov V.; Serganova I.; Kruchevsky N.; Anderson M.; Blasberg R. G.; Andreev O. A.; et al. (2014) Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer. Proc. Natl. Acad. Sci. U. S. A.111, 7254–7259. 10.1073/pnas.1405240111.24785505 [OpenAIRE] [PubMed] [DOI]

Carroll V.; Demoin D. W.; Hoffman T. J.; Jurisson S. S. (2012) Inorganic chemistry in nuclear imaging and radiotherapy: current and future directions. Radiochim. Acta 100, 653–667. 10.1524/ract.2012.1964.25382874 [OpenAIRE] [PubMed] [DOI]

Zeglis B. M.; Houghton J. L.; Evans M. J.; Viola-Villegas N.; Lewis J. S. (2014) Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals. Inorg. Chem. 53, 1880–1899. 10.1021/ic401607z.24313747 [OpenAIRE] [PubMed] [DOI]

McBride W. J.; D’souza C. A.; Sharkey R. M.; Karacay H.; Rossi E. A.; Chang C.-H.; Goldenberg D. M. (2010) Improved 18 F labeling of peptides with a fluoride-aluminum- chelate complex. Bioconjugate Chem. 21, 1331–1340. 10.1021/bc100137x. [OpenAIRE] [DOI]

22 references, page 1 of 2
Powered by OpenAIRE Research Graph
Any information missing or wrong?Report an Issue