Étude de la variabilité du génome mitochondrial comme facteur de susceptibilité au cancer du sein

Doctoral thesis French OPEN
Blein, Sophie;
(2014)
  • Publisher: HAL CCSD
  • Subject: [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM] | Mitochondrie | Mitochondria | Oxydative stress | Breast cancer | Séquençage | Stress oxydatif | Sequencing | Espèces oxygénées réactives | [ INFO.INFO-BI ] Computer Science [cs]/Bioinformatics [q-bio.QM] | Génotype | Mitochondrial haplogroups | Reactive oxygen species | Haplogroupes mitochondriaux | Cancer du sein

A large part of the genetic component of breast cancer risk (BCR) is still unexplained. Therefore I studied if variants of the mitochondrial genome (mtDNA) might explain a part of this risk. In fact, mitochondria is the main source of reactive oxygen species (ROS), whic... View more
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