Concerted action of the PHD, chromo and motor domains regulates the human chromatin remodelling ATPase CHD4

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Morra, Rosa; Lee, Benjamin M.; Shaw, Heather; Tuma, Roman; Mancini, Erika J.;

CHD4, the core subunit of the Nucleosome Remodelling and Deacetylase (NuRD) complex, is a chromatin remodelling ATPase that, in addition to a helicase domain, harbors tandem plant homeo finger and chromo domains. By using a panel of domain constructs we dissect their ro... View more
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