publication . Article . 2011

The role of imprinted genes in humans

Moore, Gudrun; Oakey, Rebecca;
Open Access English
  • Published: 01 Mar 2011 Journal: Molecular Aspects of Medicine, volume 34, issue 4, pages 826-840 (issn: 0098-2997, eissn: 1465-6914, Copyright policy)
  • Publisher: Elsevier BV
Abstract
Detailed comprehensive molecular analysis using families and multiple matched tissues is essential to determine whether imprinted genes have a functional role in humans. See research article: http://genomebiology.com/2011/12/3/R25
Subjects
free text keywords: Molecular Biology, Biochemistry, Molecular Medicine, Medicine(all), Clinical Biochemistry, Research Highlight

Scott, RJ, Spielman, M. Genomic imprinting in plants and mammals: how life history constrains convergence.. Cytogenet Genome Res. 2006; 113: 53-67 [PubMed] [DOI]

Morcos, L, Ge, B, Koka, V, Lam, KC, Pokholok, DK, Gunderson, KL, Montpetit, A, Verlaan, DJ, Pastinen, T. Genome-wide assessment of imprinted expression in human cells.. Genome Biol. 2011; 12: R25 [OpenAIRE] [DOI]

Surani, MA, Barton, SC, Norris, ML. Development of reconstituted mouse eggs suggest imprinting of the genome during gametogenesis.. Nature. 1984; 308: 548-550 [PubMed] [DOI]

McGrath, J, Solter, D. Completion of mouse embryogenesis requires both the maternal and paternal genome.. Cell. 1984; 37: 179-183 [PubMed] [DOI]

Uribe-Lewis, S, Woodfine, K, Stojic, L, Murrell, A. Molecular mechanisms of genomic imprinting and clinical implications for cancer.. Expert Rev Mol Med. 2011; 13: e2 [PubMed] [DOI]

Frost, JM, Monk, D, Stojilkovic-Mikic, T, Woodfine, K, Chitty, LS, Murrell, A, Stanier, P, Moore, GE. Evaluation of allelic expression of imprinted genes in adult human blood.. PLoS One. 2010; 5: e13556 [OpenAIRE] [PubMed] [DOI]

Monk, D, Arnaud, P, Frost, J, Hills, FA, Stanier, P, Feil, R, Moore, GE. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.. Hum Mol Genet. 2009; 18: 3066-3074 [OpenAIRE] [PubMed] [DOI]

Garfield, AS, Cowley, M, Smith, FM, Moorwood, K, Stewart-Cox, JE, Gilroy, K, Baker, S, Xia, J, Dalley, JW, Hurst, LD, Wilkinson, LS, Isles, AR, Ward, A. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.. Nature. 2011; 469: 534-538 [OpenAIRE] [PubMed] [DOI]

Monk, D, Wagschal, A, Arnaud, P, Muller, PS, Parker-Katiraee, L, Bourc'his, D, Scherer, SW, Feil, R, Stanier, P, Moore, GE. Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.. Genome Res. 2008; 18: 1270-1281 [OpenAIRE] [PubMed] [DOI]

Abstract
Detailed comprehensive molecular analysis using families and multiple matched tissues is essential to determine whether imprinted genes have a functional role in humans. See research article: http://genomebiology.com/2011/12/3/R25
Subjects
free text keywords: Molecular Biology, Biochemistry, Molecular Medicine, Medicine(all), Clinical Biochemistry, Research Highlight

Scott, RJ, Spielman, M. Genomic imprinting in plants and mammals: how life history constrains convergence.. Cytogenet Genome Res. 2006; 113: 53-67 [PubMed] [DOI]

Morcos, L, Ge, B, Koka, V, Lam, KC, Pokholok, DK, Gunderson, KL, Montpetit, A, Verlaan, DJ, Pastinen, T. Genome-wide assessment of imprinted expression in human cells.. Genome Biol. 2011; 12: R25 [OpenAIRE] [DOI]

Surani, MA, Barton, SC, Norris, ML. Development of reconstituted mouse eggs suggest imprinting of the genome during gametogenesis.. Nature. 1984; 308: 548-550 [PubMed] [DOI]

McGrath, J, Solter, D. Completion of mouse embryogenesis requires both the maternal and paternal genome.. Cell. 1984; 37: 179-183 [PubMed] [DOI]

Uribe-Lewis, S, Woodfine, K, Stojic, L, Murrell, A. Molecular mechanisms of genomic imprinting and clinical implications for cancer.. Expert Rev Mol Med. 2011; 13: e2 [PubMed] [DOI]

Frost, JM, Monk, D, Stojilkovic-Mikic, T, Woodfine, K, Chitty, LS, Murrell, A, Stanier, P, Moore, GE. Evaluation of allelic expression of imprinted genes in adult human blood.. PLoS One. 2010; 5: e13556 [OpenAIRE] [PubMed] [DOI]

Monk, D, Arnaud, P, Frost, J, Hills, FA, Stanier, P, Feil, R, Moore, GE. Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression.. Hum Mol Genet. 2009; 18: 3066-3074 [OpenAIRE] [PubMed] [DOI]

Garfield, AS, Cowley, M, Smith, FM, Moorwood, K, Stewart-Cox, JE, Gilroy, K, Baker, S, Xia, J, Dalley, JW, Hurst, LD, Wilkinson, LS, Isles, AR, Ward, A. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.. Nature. 2011; 469: 534-538 [OpenAIRE] [PubMed] [DOI]

Monk, D, Wagschal, A, Arnaud, P, Muller, PS, Parker-Katiraee, L, Bourc'his, D, Scherer, SW, Feil, R, Stanier, P, Moore, GE. Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing.. Genome Res. 2008; 18: 1270-1281 [OpenAIRE] [PubMed] [DOI]

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publication . Article . 2011

The role of imprinted genes in humans

Moore, Gudrun; Oakey, Rebecca;