A Call to Include Severe Combined Immunodeficiency in Newborn Screening Program

Article English OPEN
Raz Somech; Amos Etzioni;
(2014)
  • Publisher: Rambam Health Care Campus
  • Journal: Rambam Maimonides Medical Journal,volume 5,issue 1 (issn: 2076-9172, eissn: 2076-9172)
  • Publisher copyright policies & self-archiving
  • Related identifiers: pmc: PMC3904476, doi: 10.5041/RMMJ.10135
  • Subject: R | T cell receptor excision circles (TRECs) | R5-920 | Medicine (General) | kappa-deleting recombination excision circles (KRECs) | Guthrie cards | immunodeficiency | Medicine | neonatal screening | Science and Public Health | severe combined immunodeficiency (SCID)

Quantification of the T cell receptor excision circles (TRECs) has recently emerged as a useful non-invasive clinical and research tool to investigate thymic activity. It allows the identification of T cell production by the thymus. Quantification of TREC copies has rec... View more
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