publication . Article . Other literature type . 1993

ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release.

Bernardi, Henri; de Weille, J.R.; Epelbaum, J.; Mourre, C.; Amoroso, S.; Slama, A.; Fosset, M.; Lazdunski, M.;
Open Access English
  • Published: 15 Feb 1993
Abstract
The adenohypophysis contains high-affinity binding sites for antidiabetic sulfonylureas that are specific blockers of ATP-sensitive K+ channels. The binding protein has a M(r) of 145,000 +/- 5000. The presence of ATP-sensitive K+ channels (26 pS) has been demonstrated by electrophysiological techniques. Intracellular perfusion of adenohypophysis cells with an ATP-free medium to activate ATP-sensitive K+ channels induces a large hyperpolarization (approximately 30 mV) that is antagonized by antidiabetic sulfonylureas. Diazoxide opens ATP-sensitive K+ channels in adenohypophysis cells as it does in pancreatic beta cells and also induces a hyperpolarization (approx...
Subjects
free text keywords: potassium, canal à potassium, Research Article, adenohypophyse, adenosinetriphosphate, hypophyse, hormone de croissance
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Article . 1993
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Other literature type . 1993
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publication . Article . Other literature type . 1993

ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release.

Bernardi, Henri; de Weille, J.R.; Epelbaum, J.; Mourre, C.; Amoroso, S.; Slama, A.; Fosset, M.; Lazdunski, M.;