ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release

Other literature type, Article English OPEN
Bernardi, H; De Weille, J R; Epelbaum, J; Mourre, C; Amoroso, S; Slama, A; Fosset, M; Lazdunski, M;
(1993)
  • Related identifiers: pmc: PMC45868
  • Subject: Research Article | potassium | canal à potassium | adenohypophyse | adenosinetriphosphate | hypophyse | hormone de croissance

The adenohypophysis contains high-affinity binding sites for antidiabetic sulfonylureas that are specific blockers of ATP-sensitive K+ channels. The binding protein has a M(r) of 145,000 +/- 5000. The presence of ATP-sensitive K+ channels (26 pS) has been demonstrated b... View more
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