ATP-modulated K+ channels sensitive to antidiabetic sulfonylureas are present in adenohypophysis and are involved in growth hormone release.

Article, Other literature type English OPEN
Bernardi, H ; De Weille, J R ; Epelbaum, J ; Mourre, C ; Amoroso, S ; Slama, A ; Fosset, M ; Lazdunski, M (1993)
  • Related identifiers: pmc: PMC45868
  • Subject: potassium | canal à potassium | Research Article | adenohypophyse | adenosinetriphosphate | hypophyse | hormone de croissance

The adenohypophysis contains high-affinity binding sites for antidiabetic sulfonylureas that are specific blockers of ATP-sensitive K+ channels. The binding protein has a M(r) of 145,000 +/- 5000. The presence of ATP-sensitive K+ channels (26 pS) has been demonstrated b... View more
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