TATN-1 Mutations Reveal a Novel Role for Tyrosine as a Metabolic Signal That Influences Developmental Decisions and Longevity in Caenorhabditis elegans

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Annabel A Ferguson; Sudipa Roy; Kaitlyn N Kormanik; Yongsoon Kim; Kathleen J Dumas; Vladimir B Ritov; Dietrich Matern; Patrick J Hu; Alfred L Fisher;

Recent work has identified changes in the metabolism of the aromatic amino acid tyrosine as a risk factor for diabetes and a contributor to the development of liver cancer. While these findings could suggest a role for tyrosine as a direct regulator of the behavior of c... View more