TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.

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Annabel A Ferguson; Sudipa Roy; Kaitlyn N Kormanik; Yongsoon Kim; Kathleen J Dumas; Vladimir B Ritov; Dietrich Matern; Patrick J Hu; Alfred L Fisher;
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Genetics,volume 9,issue 12 (issn: 1553-7390, eissn: 1553-7404)
  • Related identifiers: pmc: PMC3868569, doi: 10.1371/journal.pgen.1004020
  • Subject: QH426-470 | Research Article | Genetics
    mesheuropmc: fungi

Recent work has identified changes in the metabolism of the aromatic amino acid tyrosine as a risk factor for diabetes and a contributor to the development of liver cancer. While these findings could suggest a role for tyrosine as a direct regulator of the behavior of c... View more