publication . Article . 2015

Likelihood Ratio Test for Excess Homozygosity at Marker Loci on X Chromosome.

Xiao-Ping You; Qi-Lei Zou; Jian-Long Li; Ji-Yuan Zhou;
Open Access English
  • Published: 15 Dec 2015 Journal: PLoS ONE (issn: 1932-6203, Copyright policy)
  • Publisher: Public Library of Science (PLoS)
Abstract
The assumption of Hardy-Weinberg equilibrium (HWE) is generally required for association analysis using case-control design on autosomes; otherwise, the size may be inflated. There has been an increasing interest of exploring the association between diseases and markers on X chromosome and the effect of the departure from HWE on association analysis on X chromosome. Note that there are two hypotheses of interest regarding the X chromosome: (i) the frequencies of the same allele at a locus in males and females are equal and (ii) the inbreeding coefficient in females is zero (without excess homozygosity). Thus, excess homozygosity and significantly different minor...
Subjects
free text keywords: Medicine, R, Science, Q, Research Article, Statistical hypothesis testing, Locus (genetics), Bootstrapping (electronics), Genetics, Autosome, Minor allele frequency, X chromosome, Biology, Likelihood-ratio test, Population stratification
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NIH| NARAC The Genetics of Rheumatoid Arthritis
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01AR044422-10
  • Funding stream: NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
,
NIH| Genetic Analysis of Common Diseases: An Evaluation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01GM031575-22
  • Funding stream: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
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