Decoding a cancer-relevant splicing decision in the RON proto-oncogene using high-throughput mutagenesis

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Braun, Simon; Enculescu, Mihaela; Setty, Samarth T.; Cortés-López, Mariela; de Almeida, Bernardo P.; Sutandy, F. X.  Reymond; Schulz, Laura; Busch, Anke; Seiler, Markus; Ebersberger, Stefanie; Barbosa-Morais, Nuno L.; Legewie, Stefan; König, Julian; Zarnack, Kathi;
(2018)

Mutations causing aberrant splicing are frequently implicated in human diseases including cancer. Here, we establish a high-throughput screen of randomly mutated minigenes to decode the cis-regulatory landscape that determines alternative splicing of exon 11 in the prot... View more
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