V(D)J recombination process and the Pre-B to immature B-cells transition are altered in Fanca−/− mice

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Thuy Vy Nguyen; Patrycja Pawlikowska; Virginie Firlej; Filippo Rosselli; Saïd Aoufouchi;

B-lymphocytes in the bone marrow (BM) must generate a functional B-cell receptor and overcome the negative selection induced by reactivity with autoantigens. Two rounds of DNA recombination are required for the production of functional immunoglobulin heavy (Ig-HCs) and ... View more
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