publication . Article . 2017

Cardiac Channelopathies and Sudden Death: Recent Clinical and Genetic Advances

Fernández-Falgueras, Anna; Sarquella-Brugada, Georgia; Brugada, Josep; Brugada, Ramon; Campuzano, Oscar;
Open Access English
  • Published: 29 Jan 2017 Journal: volume 6, issue 1eissn: 2079-7737, Copyright policy
  • Publisher: MDPI (Multidisciplinary Digital Publishing Institute)
Abstract
Sudden cardiac death poses a unique challenge to clinicians because it may be the only symptom of an inherited heart condition. Indeed, inherited heart diseases can cause sudden cardiac death in older and younger individuals. Two groups of familial diseases are responsible for sudden cardiac death: cardiomyopathies (mainly hypertrophic cardiomyopathy, dilated cardiomyopathy, and arrhythmogenic cardiomyopathy) and channelopathies (mainly long QT syndrome, Brugada syndrome, short QT syndrome, and catecholaminergic polymorphic ventricular tachycardia). This review focuses on cardiac channelopathies, which are characterized by lethal arrhythmias in the structurally ...
Subjects
mesheuropmc: cardiovascular system
free text keywords: Channelopathies, Arítmia, sudden cardiac death, Genètica mèdica, Mort sobtada, Ion channels, Canals iònics, Sudden death, genetics, Medical genetics, arrhythmias, Review, Arrhythmia, Canalopatíes
180 references, page 1 of 12

De Luna, A.B., Elosua, R.. Sudden death. Rev. Esp. Cardiol.. 2012; 65: 1039-1052 [OpenAIRE] [PubMed]

Pachon, M., Almendral, J.. Sudden death: Managing the patient who survives. Heart. 2011; 97: 1619-1625 [PubMed] [DOI]

Basso, C., Carturan, E., Pilichou, K., Rizzo, S., Corrado, D., Thiene, G.. Sudden cardiac death with normal heart: Molecular autopsy. Cardiovasc. Pathol.. 2010; 19: 321-325 [PubMed] [DOI]

Oliva, A., Flores, J., Merigioli, S., LeDuc, L., Benito, B., Partemi, S., Arzamendi, D., Campuzano, O., Leung, T.L., Iglesias, A.. Autopsy investigation and bayesian approach to coronary artery disease in victims of motor-vehicle accidents. Atherosclerosis. 2011; 218: 28-32 [PubMed] [DOI]

Podrid, P.J., Myerburg, R.J.. Epidemiology and stratification of risk for sudden cardiac death. Clin. Cardiol.. 2005; 28: I3-I11 [OpenAIRE] [PubMed] [DOI]

Nichol, G., Rumsfeld, J., Eigel, B., Abella, B.S., Labarthe, D., Hong, Y., O’Connor, R.E., Mosesso, V.N., Berg, R.A., Leeper, B.B.. Essential features of designating out-of-hospital cardiac arrest as a reportable event: A scientific statement from the American Heart Association Emergency Cardiovascular Care Committee; Council on Cardiopulmonary, Perioperative, And Critical Care; Council on Cardiovascular Nursing; Council on Clinical Cardiology; and Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2008; 117: 2299-2308 [PubMed]

Chugh, S.S., Senashova, O., Watts, A., Tran, P.T., Zhou, Z., Gong, Q., Titus, J.L., Hayflick, S.J.. Postmortem molecular screening in unexplained sudden death. J. Am. Coll. Cardiol.. 2004; 43: 1625-1629 [OpenAIRE] [PubMed] [DOI]

De Vreede-Swagemakers, J.J., Gorgels, A.P., Dubois-Arbouw, W.I., van Ree, J.W., Daemen, M.J., Houben, L.G., Wellens, H.J.. Out-of-hospital cardiac arrest in the 1990’s: A population-based study in the maastricht area on incidence, characteristics and survival. J. Am. Coll. Cardiol.. 1997; 30: 1500-1505 [OpenAIRE] [PubMed] [DOI]

Byrne, R., Constant, O., Smyth, Y., Callagy, G., Nash, P., Daly, K., Crowley, J.. Multiple source surveillance incidence and aetiology of out-of-hospital sudden cardiac death in a rural population in the West of Ireland. Eur. Heart J.. 2008; 29: 1418-1423 [PubMed] [DOI]

Hua, W., Zhang, L.F., Wu, Y.F., Liu, X.Q., Guo, D.S., Zhou, H.L., Gou, Z.P., Zhao, L.C., Niu, H.X., Chen, K.P.. Incidence of sudden cardiac death in China: Analysis of 4 regional populations. J. Am. Coll. Cardiol.. 2009; 54: 1110-1118 [OpenAIRE] [PubMed] [DOI]

Eckart, R.E., Shry, E.A., Burke, A.P., McNear, J.A., Appel, D.A., Castillo-Rojas, L.M., Avedissian, L., Pearse, L.A., Potter, R.N., Tremaine, L.. Sudden death in young adults: An autopsy-based series of a population undergoing active surveillance. J. Am. Coll. Cardiol.. 2011; 58: 1254-1261 [OpenAIRE] [PubMed] [DOI]

Fishman, G.I., Chugh, S.S., Dimarco, J.P., Albert, C.M., Anderson, M.E., Bonow, R.O., Buxton, A.E., Chen, P.S., Estes, M., Jouven, X.. Sudden cardiac death prediction and prevention: Report from a National Heart, Lung, And Blood Institute And Heart Rhythm Society Workshop. Circulation. 2010; 122: 2335-2348 [OpenAIRE] [PubMed] [DOI]

Myerburg, R.J., Junttila, M.J.. Sudden cardiac death caused by coronary heart disease. Circulation. 2012; 125: 1043-1052 [PubMed] [DOI]

Arzamendi, D., Benito, B., Tizon-Marcos, H., Flores, J., Tanguay, J.F., Ly, H., Doucet, S., Leduc, L., Leung, T.K., Campuzano, O.. Increase in sudden death from coronary artery disease in young adults. Am. Heart J.. 2011; 161: 574-580 [PubMed] [DOI]

Boczek, N.J., Tester, D.J., Ackerman, M.J.. The molecular autopsy: An indispensable step following sudden cardiac death in the young?. Herzschrittmacherther. Elektrophysiol.. 2012; 23: 167-173 [OpenAIRE] [PubMed] [DOI]

180 references, page 1 of 12
Abstract
Sudden cardiac death poses a unique challenge to clinicians because it may be the only symptom of an inherited heart condition. Indeed, inherited heart diseases can cause sudden cardiac death in older and younger individuals. Two groups of familial diseases are responsible for sudden cardiac death: cardiomyopathies (mainly hypertrophic cardiomyopathy, dilated cardiomyopathy, and arrhythmogenic cardiomyopathy) and channelopathies (mainly long QT syndrome, Brugada syndrome, short QT syndrome, and catecholaminergic polymorphic ventricular tachycardia). This review focuses on cardiac channelopathies, which are characterized by lethal arrhythmias in the structurally ...
Subjects
mesheuropmc: cardiovascular system
free text keywords: Channelopathies, Arítmia, sudden cardiac death, Genètica mèdica, Mort sobtada, Ion channels, Canals iònics, Sudden death, genetics, Medical genetics, arrhythmias, Review, Arrhythmia, Canalopatíes
180 references, page 1 of 12

De Luna, A.B., Elosua, R.. Sudden death. Rev. Esp. Cardiol.. 2012; 65: 1039-1052 [OpenAIRE] [PubMed]

Pachon, M., Almendral, J.. Sudden death: Managing the patient who survives. Heart. 2011; 97: 1619-1625 [PubMed] [DOI]

Basso, C., Carturan, E., Pilichou, K., Rizzo, S., Corrado, D., Thiene, G.. Sudden cardiac death with normal heart: Molecular autopsy. Cardiovasc. Pathol.. 2010; 19: 321-325 [PubMed] [DOI]

Oliva, A., Flores, J., Merigioli, S., LeDuc, L., Benito, B., Partemi, S., Arzamendi, D., Campuzano, O., Leung, T.L., Iglesias, A.. Autopsy investigation and bayesian approach to coronary artery disease in victims of motor-vehicle accidents. Atherosclerosis. 2011; 218: 28-32 [PubMed] [DOI]

Podrid, P.J., Myerburg, R.J.. Epidemiology and stratification of risk for sudden cardiac death. Clin. Cardiol.. 2005; 28: I3-I11 [OpenAIRE] [PubMed] [DOI]

Nichol, G., Rumsfeld, J., Eigel, B., Abella, B.S., Labarthe, D., Hong, Y., O’Connor, R.E., Mosesso, V.N., Berg, R.A., Leeper, B.B.. Essential features of designating out-of-hospital cardiac arrest as a reportable event: A scientific statement from the American Heart Association Emergency Cardiovascular Care Committee; Council on Cardiopulmonary, Perioperative, And Critical Care; Council on Cardiovascular Nursing; Council on Clinical Cardiology; and Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2008; 117: 2299-2308 [PubMed]

Chugh, S.S., Senashova, O., Watts, A., Tran, P.T., Zhou, Z., Gong, Q., Titus, J.L., Hayflick, S.J.. Postmortem molecular screening in unexplained sudden death. J. Am. Coll. Cardiol.. 2004; 43: 1625-1629 [OpenAIRE] [PubMed] [DOI]

De Vreede-Swagemakers, J.J., Gorgels, A.P., Dubois-Arbouw, W.I., van Ree, J.W., Daemen, M.J., Houben, L.G., Wellens, H.J.. Out-of-hospital cardiac arrest in the 1990’s: A population-based study in the maastricht area on incidence, characteristics and survival. J. Am. Coll. Cardiol.. 1997; 30: 1500-1505 [OpenAIRE] [PubMed] [DOI]

Byrne, R., Constant, O., Smyth, Y., Callagy, G., Nash, P., Daly, K., Crowley, J.. Multiple source surveillance incidence and aetiology of out-of-hospital sudden cardiac death in a rural population in the West of Ireland. Eur. Heart J.. 2008; 29: 1418-1423 [PubMed] [DOI]

Hua, W., Zhang, L.F., Wu, Y.F., Liu, X.Q., Guo, D.S., Zhou, H.L., Gou, Z.P., Zhao, L.C., Niu, H.X., Chen, K.P.. Incidence of sudden cardiac death in China: Analysis of 4 regional populations. J. Am. Coll. Cardiol.. 2009; 54: 1110-1118 [OpenAIRE] [PubMed] [DOI]

Eckart, R.E., Shry, E.A., Burke, A.P., McNear, J.A., Appel, D.A., Castillo-Rojas, L.M., Avedissian, L., Pearse, L.A., Potter, R.N., Tremaine, L.. Sudden death in young adults: An autopsy-based series of a population undergoing active surveillance. J. Am. Coll. Cardiol.. 2011; 58: 1254-1261 [OpenAIRE] [PubMed] [DOI]

Fishman, G.I., Chugh, S.S., Dimarco, J.P., Albert, C.M., Anderson, M.E., Bonow, R.O., Buxton, A.E., Chen, P.S., Estes, M., Jouven, X.. Sudden cardiac death prediction and prevention: Report from a National Heart, Lung, And Blood Institute And Heart Rhythm Society Workshop. Circulation. 2010; 122: 2335-2348 [OpenAIRE] [PubMed] [DOI]

Myerburg, R.J., Junttila, M.J.. Sudden cardiac death caused by coronary heart disease. Circulation. 2012; 125: 1043-1052 [PubMed] [DOI]

Arzamendi, D., Benito, B., Tizon-Marcos, H., Flores, J., Tanguay, J.F., Ly, H., Doucet, S., Leduc, L., Leung, T.K., Campuzano, O.. Increase in sudden death from coronary artery disease in young adults. Am. Heart J.. 2011; 161: 574-580 [PubMed] [DOI]

Boczek, N.J., Tester, D.J., Ackerman, M.J.. The molecular autopsy: An indispensable step following sudden cardiac death in the young?. Herzschrittmacherther. Elektrophysiol.. 2012; 23: 167-173 [OpenAIRE] [PubMed] [DOI]

180 references, page 1 of 12
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2017

Cardiac Channelopathies and Sudden Death: Recent Clinical and Genetic Advances

Fernández-Falgueras, Anna; Sarquella-Brugada, Georgia; Brugada, Josep; Brugada, Ramon; Campuzano, Oscar;