MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation

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Baranski, Zuzanna ; Booij, Tijmen H. ; Kuijjer, Marieke L. ; de Jong, Yvonne ; Cleton-Jansen, Anne-Marie ; Price, Leo S. ; van de Water, Bob ; Bovée, Judith V. M. G. ; Hogendoorn, Pancras C.W. ; Danen, Erik H.J. (2015)
  • Publisher: Impact Journals LLC
  • Journal: volume 6, issue 11-12, pages 503-512 (issn: 1947-6019, eissn: 1947-6027)
  • Related identifiers: pmc: PMC4701229
  • Subject: MEK | 3D culture | pharmacological inhibition | ERK phosphorylation | Research Paper | osteosarcoma

Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people. Recurrent and metastatic tumors are difficult to treat. We performed a kinase inhibitor screen in two osteosarcoma cell lines, which identified ME... View more
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