MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation
Booij, Tijmen H.
Kuijjer, Marieke L.
de Jong, Yvonne
Price, Leo S.
van de Water, Bob
Bovée, Judith V. M. G.
Hogendoorn, Pancras C.W.
Danen, Erik H.J.
- Publisher: Impact Journals LLC
(issn: 1947-6019, eissn: 1947-6027)
MEK | 3D culture | pharmacological inhibition | ERK phosphorylation | Research Paper | osteosarcoma
Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people. Recurrent and metastatic tumors are difficult to treat. We performed a kinase inhibitor screen in two osteosarcoma cell lines, which identified ME...