MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation

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Baranski, Zuzanna; Booij, Tijmen H.; Kuijjer, Marieke L.; de Jong, Yvonne; Cleton-Jansen, Anne-Marie; Price, Leo S.; van de Water, Bob; Bovée, Judith V. M. G.; Hogendoorn, Pancras C.W.; Danen, Erik H.J.;
  • Publisher: Impact Journals LLC
  • Journal: volume 6,issue 11-12,pages503-512issn: 1947-6019, eissn: 1947-6027
  • Related identifiers: pmc: PMC4701229
  • Subject: MEK | 3D culture | pharmacological inhibition | ERK phosphorylation | Research Paper | osteosarcoma

Conventional high-grade osteosarcoma is the most common primary bone cancer with relatively high incidence in young people. Recurrent and metastatic tumors are difficult to treat. We performed a kinase inhibitor screen in two osteosarcoma cell lines, which identified ME... View more
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