Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

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Wain, Louise V ; Verwoert, Germaine C ; O'Reilly, Paul F ; Shi, Gang ; Johnson, Toby ; Johnson, Andrew D ; Bochud, Murielle ; Rice, Kenneth M ; Henneman, Peter ; Smith, Albert V ; Ehret, Georg B ; Amin, Najaf ; Larson, Martin G ; Mooser, Vincent ; Hadley, David ; Dörr, Marcus ; Bis, Joshua C ; Aspelund, Thor ; Esko, Tõnu ; Janssens, A Cecile JW ; Zhao, Jing Hua ; Heath, Simon ; Laan, Maris ; Fu, Jingyuan ; Pistis, Giorgio ; Luan, Jian'an ; Arora, Pankaj ; Lucas, Gavin ; Pirastu, Nicola ; Pichler, Irene ... view all 241 authors (2011)
  • Publisher: NATURE PUBLISHING GROUP
  • Journal: volume 43, issue 10, pages 1,005-1,011 (issn: 1061-4036, eissn: 1546-1718)
  • Related identifiers: doi: 10.1038/ng.922, pmc: PMC3445021
  • Subject: CARDIOVASCULAR-DISEASE RISK | METAANALYSIS | HEART-FAILURE | GENE | MICE | Article | RELEVANCE | ADRENERGIC-RECEPTOR TRAFFICKING | MORTALITY | Medicine and Health Sciences | BLOOD-PRESSURE | HYPERTENSION
    mesheuropmc: cardiovascular diseases | circulatory and respiratory physiology

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follo... View more