Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

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Wain, LV; Verwoert, GC; O'Reilly, PF; Shi, G; Johnson, T; Johnson, AD; Bochud, M; Rice, KM; Henneman, P; Smith, AV; Ehret, GB; Amin, N; Larson, MG; Mooser, V; Hadley, D; Dörr, M; Bis, JC; Aspelund, T; Esko, T; Janssens, AC; Zhao, JH; Heath, S; Laan, M; Fu, J; Pistis, G; Luan, J; Arora, P; Lucas, G; Pirastu, N; Pichler, I; ... view all 232 authors
(2011)
  • Publisher: NATURE PUBLISHING GROUP
  • Journal: Nature genetics,volume 43,issue 10,pages1,005-1,011 (issn: 1061-4036, eissn: 1546-1718)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1038/ng.922, pmc: PMC3445021
  • Subject: CARDIOVASCULAR-DISEASE RISK | METAANALYSIS | HEART-FAILURE | GENE | MICE | RELEVANCE | Article | ADRENERGIC-RECEPTOR TRAFFICKING | MORTALITY | Medicine and Health Sciences | BLOOD-PRESSURE | HYPERTENSION
    mesheuropmc: cardiovascular diseases | circulatory and respiratory physiology

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follo... View more