SETD1A protects from senescence through regulation of the mitotic gene expression program

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Tajima, Ken; Matsuda, Satoru; Yae, Toshifumi; Drapkin, Benjamin J.; Morris, Robert; Boukhali, Myriam; Niederhoffer, Kira; Comaills, Valentine; Dubash, Taronish; Nieman, Linda; Guo, Hongshan; Magnus, Neelima K. C.; Dyson, Nick; Shioda, Toshihiro; Haas, Wilhelm; Haber, Daniel A.; Maheswaran, Shyamala;
(2019)

SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer. Here, we show that SETD1A supports mitotic processes and consequentially, its knockdown induces senescence. ... View more
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