Impact of isomalathion on malathion cytotoxicity and genotoxicity in human HepaRG cells.

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Josse , Rozenn; Sharanek , Ahmad; Savary , Camille C; Guillouzo , André; (2014)
  • Publisher: Elsevier
  • Related identifiers: doi: 10.1016/j.cbi.2013.12.002
  • Subject: Human hepatocytes | [ SDV ] Life Sciences [q-bio] | MESH : Dose-Response Relationship, Drug | MESH : Caspase 3 | Micronucleus assay | MESH : Cell Line, Tumor | Mixture | Pesticides | MESH : Cell Survival | MESH : Humans | MESH : Environmental Pollutants | MESH : Malathion | MESH : Hepatocytes | Low doses | MESH : Blotting, Western | MESH : Real-Time Polymerase Chain Reaction

International audience; Isomalathion is a major impurity of technical grade malathion, one of the most abundantly applied insecticides; however little is known about its hepatotoxicity. In the present study, cytotoxicity and genotoxicity of malathion and isomalathion ei... View more
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