Determining the validity of hospital laboratory reference intervals for healthy young adults participating in early clinical trials of candidate vaccines

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Rowland, Rosalind; O'Hara, Geraldine A; Hamill, Matthew; Poulton, Ian D; Donaldson, Hannah; Dinsmore, Laura; James, Timothy; Barnes, Eleanor; Klenerman, Paul; Gilbert, Sarah C; Hill, Adrian VS; Shine, Brian; McShane, Helen;
(2013)
  • Publisher: Landes Bioscience
  • Journal: Human Vaccines & Immunotherapeutics,volume 9,issue 8,pages1,741-1,751 (issn: 2164-5515, eissn: 2164-554X)
  • Related identifiers: pmc: PMC3906276, doi: 10.4161/hv.24998
  • Subject: healthy young adult subjects | haematological and biochemical reference intervals | pre-and post-intervention safety analysis | clinical trials | Research Paper | candidate vaccines

This was a retrospective study to determine the validity of institutional reference intervals for interpreting biochemistry and hematology results in healthy adults in the context of clinical trials of preventive vaccines. An example population of 974 healthy adults par... View more
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