Presence or absence of ocular surface inflammation directs clinical and therapeutic management of dry eye

Article English OPEN
Sambursky,Robert (2016)
  • Publisher: Dove Press
  • Journal: Clinical Ophthalmology, volume 10, pages 2,337-2,343 (issn: 1177-5483, eissn: 1177-5483)
  • Related identifiers: pmc: PMC5127432, doi: 10.2147/OPTH.S121256
  • Subject: cyclosporine | treatment | RE1-994 | Clinical Ophthalmology | inflammation | diagnosis | Ophthalmology | Original Research | dry eye | MMP-9

Robert Sambursky Coastal Eye Institute, Cornea and Comprehensive Ophthalmology, Bradenton, FL, USA Background: The presence of clinically significant inflammation has been confirmed in the tears of 40%–65% of patients with symptoms of dry eye. Ocular surface... View more
  • References (56)
    56 references, page 1 of 6

    1. Wilson SE, Stulting RD. Agreement of physician treatment practices with the international task force guidelines for diagnosis and treatment of dry eye disease. Cornea. 2007;26(3):284-289.

    2. Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine prolfies in dysfunctional tear syndrome. Am J Ophthalmol. 2009;147(2):198-205.

    3. Boehm N, Riechardt AI, Wiegand M, Pfeiffer N, Grus FH. Proinaflmma - tory cytokine prolfiing of tears from dry eye patients by means of antibody microarrays. Invest Ophthalmol Vis Sci. 2011;52(10):7725-7730.

    4. Enríquez-de-Salamanca A, Castellanos E, Stern ME, et al. Tear cytokine and chemokine analysis and clinical correlations in evaporative-type dry eye disease. Mol Vis. 2010;16:862-873.

    5. Afonso AA, Sobrin L, Monroy DC, Selzer M, Lokeshwar B, Pflugfelder SC. Tear fluid gelatinase B activity correlates with IL1- alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci. 1999;40(11):2506-2512.

    6. Sambursky R, Davitt WF 3rd, Friedberg M, Tauber S. Prospective, multicenter, clinical evaluation of point-of-care matrix metalloproteinase-9 test for confirming dry eye disease. Cornea. 2014;33(8):812-818.

    7. Kaufman HE. The practical detection of mmp-9 diagnoses ocular surface disease and may help prevent its complications. Cornea. 2013; 32(2):211-216.

    8. Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006;47(8):3293-3302.

    9. Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004; 45(12):4302-4311.

    10. Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006;82(4):588-596.

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