Ischemic Stroke Is Associated with the ABO Locus: The EuroCLOT Study

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Williams, Frances M K; Carter, Angela M; Hysi, Pirro G; Surdulescu, Gabriela; Hodgkiss, Dylan; Soranzo, Nicole; Traylor, Matthew; Bevan, Steve; Dichgans, Martin; Rothwell, Peter M W; Sudlow, Cathie; Farrall, Martin; Silander, Kaisa; Kaunisto, Mari; Wagner, Peter; Saarela, Olli; Kuulasmaa, Kari; Virtamo, Jarmo; Salomaa, Veikko; Amouyel, Philippe; Arveiler, Dominique; Ferrieres, Jean; Wiklund, Per-Gunnar; Arfan Ikram, M; Hofman, Albert; Boncoraglio, Giorgio B; Parati, Eugenio A; Helgadottir, Anna; Gretarsdottir, Solveig; Thorsteinsdottir, Unnur; ... view all 58 authors
  • Publisher: WILEY-BLACKWELL
  • Journal: Annals of Neurology, volume 73, issue 1, pages 16-31 (issn: 0364-5134, eissn: 1531-8249)
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  • Related identifiers: pmc: PMC3582024, doi: 10.1002/ana.23838
  • Subject: ABO Blood-Group System; genetics, Adolescent, Adult, Aged, Aged; 80 and over, Blood Coagulation; genetics, Brain Ischemia; diagnosis/epidemiology/genetics, Cohort Studies, Europe; epidemiology, Female, Genetic Loci; genetics, Genetic Predisposition to Disease; epidemiology/genetics, Genetic Variation; genetics, Genome-Wide Association Study; methods, Humans, Male, Middle Aged, Polymorphism; Single Nucleotide; genetics, Stroke; diagnosis/epidemiology/genetics, Young Adult | Rapid Communication

OBJECTIVE: End-stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end-stage coagulation in healthy volunteers account for the genetic predisposition to ischem... View more